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Pharmaceuticals 2015, 8(1), 40-61; doi:10.3390/ph8010040

γδ T Cell Immunotherapy—A Review

1
Transfusion Medicine and Cell Processing, Department of Urology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
2
Center for Therapeutic Innovation, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Shin Mineishi
Received: 6 January 2015 / Accepted: 2 February 2015 / Published: 12 February 2015
(This article belongs to the Special Issue Cell Therapy)
View Full-Text   |   Download PDF [778 KB, uploaded 12 February 2015]   |  

Abstract

Cancer immunotherapy utilizing Vγ9Vδ2 T cells has been developed over the past decade. A large number of clinical trials have been conducted on various types of solid tumors as well as hematological malignancies. Vγ9Vδ2 T cell-based immunotherapy can be classified into two categories based on the methods of activation and expansion of these cells. Although the in vivo expansion of Vγ9Vδ2 T cells by phosphoantigens or nitrogen-containing bisphosphonates (N-bis) has been translated to early-phase clinical trials, in which the safety of the treatment was confirmed, problems such as activation-induced Vγ9Vδ2 T cell anergy and a decrease in the number of peripheral blood Vγ9Vδ2 T cells after infusion of these stimulants have not yet been solved. In addition, it is difficult to ex vivo expand Vγ9Vδ2 T cells from advanced cancer patients with decreased initial numbers of peripheral blood Vγ9Vδ2 T cells. In this article, we review the clinical studies and reports targeting Vγ9Vδ2 T cells and discuss the development and improvement of Vγ9Vδ2 T cell-based cancer immunotherapy. View Full-Text
Keywords: cancer immunotherapy; nitrogen-containing bisphosphonate; phosphoantigen; tumor; Vγ9Vδ2 T cell cancer immunotherapy; nitrogen-containing bisphosphonate; phosphoantigen; tumor; Vγ9Vδ2 T cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kobayashi, H.; Tanaka, Y. γδ T Cell Immunotherapy—A Review. Pharmaceuticals 2015, 8, 40-61.

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