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Pharmaceuticals 2014, 7(7), 765-778; doi:10.3390/ph7070765

Imaging Biomarkers or Biomarker Imaging?

Radiochemistry and Biomarker Development Unit, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 9 January 2014 / Revised: 13 June 2014 / Accepted: 17 June 2014 / Published: 25 June 2014
(This article belongs to the Special Issue Radiopharmaceutical Chemistry between Imaging and Radioendotherapy)
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Since biomarker imaging is traditionally understood as imaging of molecular probes, we highly recommend to avoid any confusion with the previously defined term “imaging biomarkers” and, therefore, only use “molecular probe imaging (MPI)” in that context. Molecular probes (MPs) comprise all kinds of molecules administered to an organism which inherently carry a signalling moiety. This review highlights the basic concepts and differences of molecular probe imaging using specific biomarkers. In particular, PET radiopharmaceuticals are discussed in more detail. Specific radiochemical and radiopharmacological aspects as well as some legal issues are presented.
Keywords: tracer; molecular probe; PET; radiopharmaceutical tracer; molecular probe; PET; radiopharmaceutical
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mitterhauser, M.; Wadsak, W. Imaging Biomarkers or Biomarker Imaging? Pharmaceuticals 2014, 7, 765-778.

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