Pharmaceuticals 2013, 6(5), 650-658; doi:10.3390/ph6050650
Review

Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors

1 Laboratory of Cellular Communication, Oswaldo Cruz Institute–FIOCRUZ, Rio de Janeiro 21040-360, Brazil 2 Laboratory of Immunopharmacology, Oswaldo Cruz Institute–FIOCRUZ, Rio de Janeiro 21040-360, Brazil
* Author to whom correspondence should be addressed.
Received: 4 March 2013; in revised form: 18 April 2013 / Accepted: 22 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Purine and Its Derivatives)
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Abstract: Natural products have reemerged in traditional medicine as a potential source of new molecules or phytomedicines to help with health disorders. It has been established that members of the P2X subfamily, ATP-gated ion channels, are crucial to the inflammatory process and pain signalization. As such, several preclinical studies have demonstrated that P2X2R, P2X3R, P2X4R and P2X7R are promising pharmacological targets to control inflammatory and pain disorders. Several studies have indicated that natural products could be a good source of the new specific molecules needed for the treatment of diseases linked to inflammation and pain disorders through the regulation of these receptors. Herein, we discuss and give an overview of the applicability of natural products as a source to obtain P2X receptors (P2XR) selective antagonists for use in clinical treatment, which require further investigation.
Keywords: natural products; phytotherapy; purinergic receptors; inflammation and pain

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MDPI and ACS Style

Soares-Bezerra, R.J.; Calheiros, A.S.; da Silva Ferreira, N.C.; da Silva Frutuoso, V.; Alves, L.A. Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors. Pharmaceuticals 2013, 6, 650-658.

AMA Style

Soares-Bezerra RJ, Calheiros AS, da Silva Ferreira NC, da Silva Frutuoso V, Alves LA. Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors. Pharmaceuticals. 2013; 6(5):650-658.

Chicago/Turabian Style

Soares-Bezerra, Rômulo J.; Calheiros, Andrea S.; da Silva Ferreira, Natiele C.; da Silva Frutuoso, Valber; Alves, Luiz A. 2013. "Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors." Pharmaceuticals 6, no. 5: 650-658.

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