a-Anilinoketones, Esters and Amides: A Chemical Study
AbstractA group of a-anilinoketones, 2-aminoalcohols, a-anilinoesters and a-anilinoamides were successfully synthesized and characterized by NMR spectroscopy and mass spectrometry. The yields were, in general, moderate to good (up to 75.4%), except for the a-anilinoesters (16.9–35.6%). The a-halocarbonyl starting materials showed different chemical reactivities. a-Haloketones and a-chloroacetates afforded monoalkylation, while small a-chloroamides afforded dialkylation. Finally, NMR spectroscopy revealed interesting structural features about the 2-aminoalcohols and diphenylamides.
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Qandil, A.M.; Fakhouri, L.I. a-Anilinoketones, Esters and Amides: A Chemical Study. Pharmaceuticals 2012, 5, 591-612.
Qandil AM, Fakhouri LI. a-Anilinoketones, Esters and Amides: A Chemical Study. Pharmaceuticals. 2012; 5(6):591-612.Chicago/Turabian Style
Qandil, Amjad M.; Fakhouri, Lara I. 2012. "a-Anilinoketones, Esters and Amides: A Chemical Study." Pharmaceuticals 5, no. 6: 591-612.