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A correction was published on 24 September 2012, see Pharmaceuticals 2012, 5(9), 1044.

Pharmaceuticals 2012, 5(5), 460-468; doi:10.3390/ph5050460
Article

Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines

1,2
Received: 18 March 2012; in revised form: 18 April 2012 / Accepted: 27 April 2012 / Published: 3 May 2012
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Abstract: A group of benzimidazole analogs of sildenafil, 3-benzimidazolyl-4-methoxy-phenylsulfonylpiperazines 2–4 and 3-benzimidazolyl-4-methoxy-N,N-dimethyl- benzenesulfonamide (5), were efficiently synthesized. Compounds 2–5 were characterized by NMR and MS and contrary to the reported mass spectra of sildenafil, the spectra of the piperazine-containing compounds 2–4 showed a novel fragmentation pattern leading to an m/z = 316. A mechanism for the formation of this fragment was proposed.
Keywords: phenyl sulfonylpiperazine; benzimidazole; mass spectrometry; NMR phenyl sulfonylpiperazine; benzimidazole; mass spectrometry; NMR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Qandil, A.M. Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines. Pharmaceuticals 2012, 5, 460-468.

AMA Style

Qandil AM. Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines. Pharmaceuticals. 2012; 5(5):460-468.

Chicago/Turabian Style

Qandil, Amjad M. 2012. "Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines." Pharmaceuticals 5, no. 5: 460-468.



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