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• Smith, FG.
• Wade, AW.
• Lewis, ML.
• Qi, W
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• Smith, FG.
• Wade, AW.
• Lewis, ML.
• Qi, W
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• Smith, FG.
• Wade, AW.
• Lewis, ML.
• Qi, W

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Pharmaceuticals 2012, 5(11), 1160-1176; doi:10.3390/ph5111160

Review

Cyclooxygenase (COX) Inhibitors and the Newborn Kidney

Francine G. Smith ^1,2,* , Andrew W. Wade ^2,3 , Megan L. Lewis ^1,2  and Wei Qi ^1,2

¹ Department of Physiology and Pharmacology, University of Calgary, Alberta, T2N 4N1, Canada ² Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Alberta, T2N 4N1, Canada ³ Department of Pediatrics, University of Calgary, Alberta, T2N 4N1, Canada

* Author to whom correspondence should be addressed.

Received: 17 August 2012; in revised form: 28 September 2012 / Accepted: 15 October 2012 / Published: 25 October 2012

(This article belongs to the Special Issue Cyclooxygenase(COX) Inhibitors)

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Abstract: This review summarizes our current understanding of the role of cyclo-oxygenase inhibitors (COXI) in influencing the structural development as well as the function of the developing kidney. COXI administered either during pregnancy or after birth can influence kidney development including nephronogenesis, and can decrease renal perfusion and ultrafiltration potentially leading to acute kidney injury in the newborn period. To date, which COX isoform (COX-1 or COX-2) plays a more important role in during fetal development and influences kidney function early in life is not known, though evidence points to a predominant role for COX-2. Clinical implications of the use of COXI in pregnancy and in the newborn infant are also evaluated herein, with specific reference to the potential effects of COXI on nephronogenesis as well as newborn kidney function.

Keywords: perinatal; prostaglandins; newborn; patent ductus arteriosis; premature labour; indomethacin; COX-1; COX-2; neonate; COX inhibitors

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