Pharmaceuticals 2012, 5(11), 1160-1176; doi:10.3390/ph5111160
Review

Cyclooxygenase (COX) Inhibitors and the Newborn Kidney

1,2,* email, 2,3, 1,2 and 1,2
Received: 17 August 2012; in revised form: 28 September 2012 / Accepted: 15 October 2012 / Published: 25 October 2012
(This article belongs to the Special Issue Cyclooxygenase(COX) Inhibitors)
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Abstract: This review summarizes our current understanding of the role of cyclo-oxygenase inhibitors (COXI) in influencing the structural development as well as the function of the developing kidney. COXI administered either during pregnancy or after birth can influence kidney development including nephronogenesis, and can decrease renal perfusion and ultrafiltration potentially leading to acute kidney injury in the newborn period. To date, which COX isoform (COX-1 or COX-2) plays a more important role in during fetal development and influences kidney function early in life is not known, though evidence points to a predominant role for COX-2. Clinical implications of the use of COXI in pregnancy and in the newborn infant are also evaluated herein, with specific reference to the potential effects of COXI on nephronogenesis as well as newborn kidney function.
Keywords: perinatal; prostaglandins; newborn; patent ductus arteriosis; premature labour; indomethacin; COX-1; COX-2; neonate; COX inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Smith, F.G.; Wade, A.W.; Lewis, M.L.; Qi, W. Cyclooxygenase (COX) Inhibitors and the Newborn Kidney. Pharmaceuticals 2012, 5, 1160-1176.

AMA Style

Smith FG, Wade AW, Lewis ML, Qi W. Cyclooxygenase (COX) Inhibitors and the Newborn Kidney. Pharmaceuticals. 2012; 5(11):1160-1176.

Chicago/Turabian Style

Smith, Francine G.; Wade, Andrew W.; Lewis, Megan L.; Qi, Wei. 2012. "Cyclooxygenase (COX) Inhibitors and the Newborn Kidney." Pharmaceuticals 5, no. 11: 1160-1176.


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