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• Tarinc, D
• Golcu, A
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• Tarinc, D
• Golcu, A

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Pharmaceuticals 2011, 4(7), 964-975; doi:10.3390/ph4070964

Article

Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II)

Mustafa Cesme, Derya Tarinc and Aysegul Golcu*

Department of Chemistry, Faculty of Science and Arts, University of Kahramanmaraş Sütçü Imam, Campuse of Avsar, 46100, Kahramanmaras, Turkey

* Author to whom correspondence should be addressed.

Received: 10 March 2011; in revised form: 27 April 2011 / Accepted: 18 May 2011 / Published: 28 June 2011

(This article belongs to the Special Issue Betablockers)

Download PDF Full-Text [262 KB, uploaded 28 June 2011 14:09 CEST]

Abstract: A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer’s law within the concentration range 8.5-70 mg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 mg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu₂MPT₂Cl₂) have been reported.

Keywords: b-blockers; metoprolol; complexation; spectrophotometry

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