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Pharmaceuticals 2011, 4(11), 1450-1474; doi:10.3390/ph4111450
Review

Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach

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Received: 8 August 2011 / Revised: 20 October 2011 / Accepted: 20 October 2011 / Published: 27 October 2011
(This article belongs to the Special Issue Advances in Drug Design)

Abstract

The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer’s disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as obesity and sexual dysfunction. Although inflammation is not the direct cause of these disorders, inflammatory processes often increase related pain and suffering. New anti-inflammatory drugs developed using molecular hybridization techniques to obtain multiple-ligand drugs can act at one or multiple targets, allowing for synergic action and minimizing toxicity. This work is a review of new anti-inflammatory drugs developed using the molecular modification approach.
Keywords: anti-inflammatory; hybridization; multiple-ligands; mutual prodrug anti-inflammatory; hybridization; multiple-ligands; mutual prodrug
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bosquesi, P.L.; Melo, T.R.F.; Vizioli, E.O.; Santos, J.L.; Chung, M.C. Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach. Pharmaceuticals 2011, 4, 1450-1474.

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