Abstract: The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer’s disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as obesity and sexual dysfunction. Although inflammation is not the direct cause of these disorders, inflammatory processes often increase related pain and suffering. New anti-inflammatory drugs developed using molecular hybridization techniques to obtain multiple-ligand drugs can act at one or multiple targets, allowing for synergic action and minimizing toxicity. This work is a review of new anti-inflammatory drugs developed using the molecular modification approach.
Keywords: anti-inflammatory; hybridization; multiple-ligands; mutual prodrug
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Bosquesi, P.L.; Melo, T.R.F.; Vizioli, E.O.; Santos, J.L.; Chung, M.C. Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach. Pharmaceuticals 2011, 4, 1450-1474.
Bosquesi PL, Melo TRF, Vizioli EO, Santos JL, Chung MC. Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach. Pharmaceuticals. 2011; 4(11):1450-1474.
Bosquesi, Priscila Longhin; Melo, Thais Regina Ferreira; Vizioli, Ednir Oliveira; Santos, Jean Leandro dos; Chung, Man Chin. 2011. "Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach." Pharmaceuticals 4, no. 11: 1450-1474.