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Stem Cell Therapy: A New Treatment for Burns?
Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
Plastic Surgery Department and Burn Unit, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Passeig de la Vall d’Hebron 119-129, 08035, Barcelona, Spain
Department of Dermatology and Allergology, Ludwig Maximilians University, Geschwister-Scholl-Platz 1, 80539, Munich, Germany
* Author to whom correspondence should be addressed.
Received: 12 July 2011; in revised form: 21 September 2011 / Accepted: 10 October 2011 / Published: 21 October 2011
Abstract: Stem cell therapy has emerged as a promising new approach in almost every medicine specialty. This vast, heterogeneous family of cells are now both naturally (embryonic and adult stem cells) or artificially obtained (induced pluripotent stem cells or iPSCs) and their fates have become increasingly controllable, thanks to ongoing research in this passionate new field. We are at the beginning of a new era in medicine, with multiple applications for stem cell therapy, not only as a monotherapy, but also as an adjunct to other strategies, such as organ transplantation or standard drug treatment. Regrettably, serious preclinical concerns remain and differentiation, cell fusion, senescence and signalling crosstalk with growth factors and biomaterials are still challenges for this promising multidisciplinary therapeutic modality. Severe burns have several indications for stem cell therapy, including enhancement of wound healing, replacement of damaged skin and perfect skin regeneration – incorporating skin appendages and reduced fibrosis –, as well as systemic effects, such as inflammation, hypermetabolism and immunosuppression. The aim of this review is to describe well established characteristics of stem cells and to delineate new advances in the stem cell field, in the context of burn injury and wound healing.
Keywords: stem cells; burn; tissue engineering; regenerative medicine
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MDPI and ACS Style
Arno, A.; Smith, A.H.; Blit, P.H.; Shehab, M.A.; Gauglitz, G.G.; Jeschke, M.G. Stem Cell Therapy: A New Treatment for Burns? Pharmaceuticals 2011, 4, 1355-1380.
Arno A, Smith AH, Blit PH, Shehab MA, Gauglitz GG, Jeschke MG. Stem Cell Therapy: A New Treatment for Burns? Pharmaceuticals. 2011; 4(10):1355-1380.
Arno, Anna; Smith, Alexandra H.; Blit, Patrick H.; Shehab, Mohammed Al; Gauglitz, Gerd G.; Jeschke, Marc G. 2011. "Stem Cell Therapy: A New Treatment for Burns?" Pharmaceuticals 4, no. 10: 1355-1380.