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Rational Polytherapy with Antiepileptic Drugs
The Edward B. Bromfield Epilepsy Program, Division of EEG, Epilepsy, and Sleep Neurology, Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA
* Author to whom correspondence should be addressed.
Received: 30 June 2010; in revised form: 21 July 2010 / Accepted: 22 July 2010 / Published: 26 July 2010
Abstract: Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies in this field, and the challenges in finding such optimal combinations. Several case scenarios are presented, illustrating examples of rational polytherapy.
Keywords: antiepileptic drug; rational polytherapy; epilepsy
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Cite This Article
MDPI and ACS Style
Lee, J.W.; Dworetzky, B. Rational Polytherapy with Antiepileptic Drugs. Pharmaceuticals 2010, 3, 2362-2379.
Lee JW, Dworetzky B. Rational Polytherapy with Antiepileptic Drugs. Pharmaceuticals. 2010; 3(8):2362-2379.
Lee, Jong Woo; Dworetzky, Barbara. 2010. "Rational Polytherapy with Antiepileptic Drugs." Pharmaceuticals 3, no. 8: 2362-2379.