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Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development
Pharmaceuticals 2010, 3(8), 2362-2379; doi:10.3390/ph3082362

Rational Polytherapy with Antiepileptic Drugs

*  and
The Edward B. Bromfield Epilepsy Program, Division of EEG, Epilepsy, and Sleep Neurology, Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA
* Author to whom correspondence should be addressed.
Received: 30 June 2010 / Revised: 21 July 2010 / Accepted: 22 July 2010 / Published: 26 July 2010
(This article belongs to the Special Issue Antiepileptic Drugs)
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Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies in this field, and the challenges in finding such optimal combinations. Several case scenarios are presented, illustrating examples of rational polytherapy.
Keywords: antiepileptic drug; rational polytherapy; epilepsy antiepileptic drug; rational polytherapy; epilepsy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, J.W.; Dworetzky, B. Rational Polytherapy with Antiepileptic Drugs. Pharmaceuticals 2010, 3, 2362-2379.

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