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• Meek, I
• Van de Laar, M
• E. Vonkeman, H
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• Meek, I
• Van de Laar, M
• E. Vonkeman, H
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• Meek, I
• Van de Laar, M
• E. Vonkeman, H

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Pharmaceuticals 2010, 3(7), 2146-2162; doi:10.3390/ph3072146

Review

Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks

Inger L. Meek, Mart A.F.J. Van de Laar and Harald E. Vonkeman*

Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente and University of Twente, Ariensplein 1, 7500 KA Enschede, The Netherlands

* Author to whom correspondence should be addressed.

Received: 17 June 2010; in revised form: 30 June 2010 / Accepted: 1 July 2010 / Published: 7 July 2010

(This article belongs to the Special Issue Non-Steroidal Anti-Inflammatory Drugs)

Download PDF Full-Text [163 KB, uploaded 7 July 2010 08:54 CEST]

Abstract: While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general "black box" warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causing hypertension, edema and heart failure, the cardiovascular effects causing myocardial infarction and stroke, and the possible deleterious interaction between NSAIDs and aspirin.

Keywords: NSAIDs; aspirin; cardiovascular events

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