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NSAIDs in the Acute Treatment of Migraine: A Review of Clinical and Experimental Data
Pharmaceuticals 2010, 3(7), 2007-2021; doi:10.3390/ph3072007
Review

NSAIDs and Cell Proliferation in Colorectal Cancer

* ,
 and
Received: 8 April 2010; in revised form: 17 May 2010 / Accepted: 22 June 2010 / Published: 24 June 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
View Full-Text   |   Download PDF [132 KB, uploaded 24 June 2010]
Abstract: Colon cancer is common worldwide and accounts for significant morbidity and mortality in patients. Fortunately, epidemiological studies have demonstrated that continuous therapy with NSAIDs offers real promise of chemoprevention and adjunct therapy for colon cancer patients. Tumour growth is the result of complex regulation that determines the balance between cell proliferation and cell death. How NSAIDs affect this balance is important for understanding and improving treatment strategies and drug effectiveness. NSAIDs inhibit proliferation and impair the growth of colon cancer cell lines when tested in culture in vitro and many NSAIDs also prevent tumorigenesis and reduce tumour growth in animal models and in patients, but the relationship to inhibition of tumour cell proliferation is less convincing, principally due to gaps in the available data. High concentrations of NSAIDs are required in vitro to achieve cancer cell inhibition and growth retardation at varying time-points following treatment. However, the results from studies with colon cancer cell xenografts are promising and, together with better comparative data on anti-proliferative NSAID concentrations and doses (for in vitro and in vivo administration), could provide more information to improve our understanding of the relationships between these agents, dose and dosing regimen, and cellular environment.
Keywords: colon cancer; cyclooxygenase; COX inhibitors colon cancer; cyclooxygenase; COX inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ettarh, R.; Cullen, A.; Calamai, A. NSAIDs and Cell Proliferation in Colorectal Cancer. Pharmaceuticals 2010, 3, 2007-2021.

AMA Style

Ettarh R, Cullen A, Calamai A. NSAIDs and Cell Proliferation in Colorectal Cancer. Pharmaceuticals. 2010; 3(7):2007-2021.

Chicago/Turabian Style

Ettarh, Raj; Cullen, Anthony; Calamai, Alvise. 2010. "NSAIDs and Cell Proliferation in Colorectal Cancer." Pharmaceuticals 3, no. 7: 2007-2021.


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