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Pharmaceuticals 2018, 11(1), 6; doi:10.3390/ph11010006

Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage

Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil
Federal Institute of Education, Science and Technology of Ceará, Armando Sales Louzada Street, 62580-000 Acaraú, Brazil
Department of Morphoology, Faculty of Medicine, Federal University of Ceará, s/n Delmiro de Farias Street, Porangabuçu Campus, 60416-030 Fortaleza, Brazil
Author to whom correspondence should be addressed.
Received: 11 October 2017 / Revised: 17 November 2017 / Accepted: 19 November 2017 / Published: 20 January 2018
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The development of the gastric lesion is complex and the result of the imbalance between aggressive and protective factors, involving the generation of free radicals and disturbance in nitric oxide (NO) production. Sulphated polysaccharides (SP), from marine algae, are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of SP from the green marine alga Caulerpa mexicana (Cm-SP) in ethanol-induced gastric damage models in mice. Cm-SP (2, 20, or 200 mg/kg), administered p.o., significantly reduced gastric damage, and these effects were inhibited through pretreatment with indomethacin. Cm-SP (200 mg/kg) prevented the ethanol-induced decline in glutathione and restored its normal level. Moreover, it was able to normalize the elevated thiobarbituric acid reactive substance levels. However, Cm-SP did not show any significant effects on NO2/NO3 level, when compared to the ethanol group. The pretreatment with L- NAME induced gastric mucosal damage and did not inhibit the gastroprotective effect of Cm-SP (200 mg/kg). In conclusion, the gastroprotective effects of Cm-SP in mice involve prostaglandins and reduction in the oxidative stress and are independent of NO. View Full-Text
Keywords: marine alga; gastric ulcer; gastroprotection; cytoprotection marine alga; gastric ulcer; gastroprotection; cytoprotection

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Carneiro, J.G.; Holanda, T.B.L.; Quinderé, A.L.G.; Frota, A.F.; Soares, V.V.M.; Sousa, R.S.; Carneiro, M.A.; Martins, D.S.; Gomes Duarte, A.S.; Benevides, N.M.B. Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage. Pharmaceuticals 2018, 11, 6.

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