Next Article in Journal
Glycosaminoglycans and Proteoglycans
Previous Article in Journal / Special Issue
Characterization of the Lytic Capability of a LysK-Like Endolysin, Lys-phiSA012, Derived from a Polyvalent Staphylococcus aureus Bacteriophage
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview
Pharmaceuticals 2018, 11(1), 26; doi:10.3390/ph11010026

Semi-Solid and Solid Dosage Forms for the Delivery of Phage Therapy to Epithelia

Department of Pharmacy and Applied Science, La Trobe Institute for Molecular Science, La Trobe University Bendigo Campus, PO Box 199, Bendigo 3550, Australia
Department of Physiology, Anatomy and Microbiology, La Trobe University Bundoora, Bundoora 3083, Australia
Department of Microbiology, Royal Melbourne Hospital, Parkville 3050, Australia
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 12 February 2018 / Accepted: 23 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue Phage Therapy and Phage-Mediated Biological Control)
View Full-Text   |   Download PDF [1690 KB, uploaded 26 February 2018]   |  


The delivery of phages to epithelial surfaces for therapeutic outcomes is a realistic proposal, and indeed one which is being currently tested in clinical trials. This paper reviews some of the known research on formulation of phages into semi-solid dosage forms such as creams, ointments and pastes, as well as solid dosage forms such as troches (or lozenges and pastilles) and suppositories/pessaries, for delivery to the epithelia. The efficacy and stability of these phage formulations is discussed, with a focus on selection of optimal semi-solid bases for phage delivery. Issues such as the need for standardisation of techniques for formulation as well as for assessment of efficacy are highlighted. These are important when trying to compare results from a range of experiments and across different delivery bases. View Full-Text
Keywords: phages; phage therapy; phage formulation phages; phage therapy; phage formulation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Brown, T.L.; Petrovski, S.; Chan, H.T.; Angove, M.J.; Tucci, J. Semi-Solid and Solid Dosage Forms for the Delivery of Phage Therapy to Epithelia. Pharmaceuticals 2018, 11, 26.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top