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Pharmaceuticals 2018, 11(1), 26; https://doi.org/10.3390/ph11010026

Semi-Solid and Solid Dosage Forms for the Delivery of Phage Therapy to Epithelia

1
Department of Pharmacy and Applied Science, La Trobe Institute for Molecular Science, La Trobe University Bendigo Campus, PO Box 199, Bendigo 3550, Australia
2
Department of Physiology, Anatomy and Microbiology, La Trobe University Bundoora, Bundoora 3083, Australia
3
Department of Microbiology, Royal Melbourne Hospital, Parkville 3050, Australia
*
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 12 February 2018 / Accepted: 23 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue Phage Therapy and Phage-Mediated Biological Control)
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Abstract

The delivery of phages to epithelial surfaces for therapeutic outcomes is a realistic proposal, and indeed one which is being currently tested in clinical trials. This paper reviews some of the known research on formulation of phages into semi-solid dosage forms such as creams, ointments and pastes, as well as solid dosage forms such as troches (or lozenges and pastilles) and suppositories/pessaries, for delivery to the epithelia. The efficacy and stability of these phage formulations is discussed, with a focus on selection of optimal semi-solid bases for phage delivery. Issues such as the need for standardisation of techniques for formulation as well as for assessment of efficacy are highlighted. These are important when trying to compare results from a range of experiments and across different delivery bases. View Full-Text
Keywords: phages; phage therapy; phage formulation phages; phage therapy; phage formulation
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Brown, T.L.; Petrovski, S.; Chan, H.T.; Angove, M.J.; Tucci, J. Semi-Solid and Solid Dosage Forms for the Delivery of Phage Therapy to Epithelia. Pharmaceuticals 2018, 11, 26.

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