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Pharmaceuticals 2017, 10(3), 64; https://doi.org/10.3390/ph10030064

Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts

1
AbbVie Inc, 1 North Waukegan Road, North Chicago, IL 60064, USA
2
Baptist Medical Center, 800 Prudential Drive, Jacksonville, FL 32207, USA
*
Author to whom correspondence should be addressed.
Received: 25 June 2017 / Revised: 26 June 2017 / Accepted: 26 June 2017 / Published: 6 July 2017
View Full-Text   |   Download PDF [161 KB, uploaded 6 July 2017]

Abstract

2017 marks the 20th anniversary of the molecular cloning by David Julius and colleagues (1997) of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1) [1]. This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count 28 mammalian members, 27 in humans) of TRP ion channels [2]. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials [3]. Yet, despite the large amount of resources that has been invested in TRPV1 research, there are currently no TRPV1-targeted drugs in phase 3 clinical trials. In this special issue of Pharmaceuticals, we aim to capture the progress in the TRP channel field over the past twenty years, with 15 articles covering a variety of TRP channels and potential relevant disease states and applications. View Full-Text
Keywords: Transient Receptor Potential Channels; TRP; Drug Discovery Transient Receptor Potential Channels; TRP; Drug Discovery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Huang, S.; Szallasi, A. Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts. Pharmaceuticals 2017, 10, 64.

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