Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
Abstract2017 marks the 20th anniversary of the molecular cloning by David Julius and colleagues (1997) of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1) . This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count 28 mammalian members, 27 in humans) of TRP ion channels . Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials . Yet, despite the large amount of resources that has been invested in TRPV1 research, there are currently no TRPV1-targeted drugs in phase 3 clinical trials. In this special issue of Pharmaceuticals, we aim to capture the progress in the TRP channel field over the past twenty years, with 15 articles covering a variety of TRP channels and potential relevant disease states and applications. View Full-Text
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Huang, S.; Szallasi, A. Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts. Pharmaceuticals 2017, 10, 64.
Huang S, Szallasi A. Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts. Pharmaceuticals. 2017; 10(3):64.Chicago/Turabian Style
Huang, Susan; Szallasi, Arpad. 2017. "Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts." Pharmaceuticals 10, no. 3: 64.
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