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Pharmaceuticals 2017, 10(1), 21; doi:10.3390/ph10010021

The Link between Protein Kinase CK2 and Atypical Kinase Rio1

The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland
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Academic Editor: Lorenzo Pinna
Received: 30 November 2016 / Revised: 27 January 2017 / Accepted: 4 February 2017 / Published: 7 February 2017
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Abstract

The atypical kinase Rio1 is widespread in many organisms, ranging from Archaebacteria to humans, and is an essential factor in ribosome biogenesis. Little is known about the protein substrates of the enzyme and small-molecule inhibitors of the kinase. Protein kinase CK2 was the first interaction partner of Rio1, identified in yeast cells. The enzyme from various sources undergoes CK2-mediated phosphorylation at several sites and this modification regulates the activity of Rio1. The aim of this review is to present studies of the relationship between the two different kinases, with respect to CK2-mediated phosphorylation of Rio1, regulation of Rio1 activity, and similar susceptibility of the kinases to benzimidazole inhibitors. View Full-Text
Keywords: protein kinase CK2; protein kinase Rio1; phosphorylation; protein-protein interaction; benzimidazoles protein kinase CK2; protein kinase Rio1; phosphorylation; protein-protein interaction; benzimidazoles
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Kubiński, K.; Masłyk, M. The Link between Protein Kinase CK2 and Atypical Kinase Rio1. Pharmaceuticals 2017, 10, 21.

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