Sensors 2009, 9(9), 7398-7411; doi:10.3390/s90907398
Article

Chalcogenide Glass Optical Waveguides for Infrared Biosensing

1, 1, 1,* email, 2, 3, 1, 4, 5, 6, 7, 8, 8, 8 and 1email
Received: 8 July 2009; in revised form: 4 September 2009 / Accepted: 8 September 2009 / Published: 15 September 2009
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Japan)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Due to the remarkable properties of chalcogenide (Chg) glasses, Chg optical waveguides should play a significant role in the development of optical biosensors. This paper describes the fabrication and properties of chalcogenide fibres and planar waveguides. Using optical fibre transparent in the mid-infrared spectral range we have developed a biosensor that can collect information on whole metabolism alterations, rapidly and in situ. Thanks to this sensor it is possible to collect infrared spectra by remote spectroscopy, by simple contact with the sample. In this way, we tried to determine spectral modifications due, on the one hand, to cerebral metabolism alterations caused by a transient focal ischemia in the rat brain and, in the other hand, starvation in the mouse liver. We also applied a microdialysis method, a well known technique for in vivo brain metabolism studies, as reference. In the field of integrated microsensors, reactive ion etching was used to pattern rib waveguides between 2 and 300 μm wide. This technique was used to fabricate Y optical junctions for optical interconnections on chalcogenide amorphous films, which can potentially increase the sensitivity and stability of an optical micro-sensor. The first tests were also carried out to functionalise the Chg planar waveguides with the aim of using them as (bio)sensors.
Keywords: chalcogenide; optical sensor; fibre; planar waveguide
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MDPI and ACS Style

Anne, M.-L.; Keirsse, J.; Nazabal, V.; Hyodo, K.; Inoue, S.; Boussard-Pledel, C.; Lhermite, H.; Charrier, J.; Yanakata, K.; Loreal, O.; Le Person, J.; Colas, F.; Compère, C.; Bureau, B. Chalcogenide Glass Optical Waveguides for Infrared Biosensing. Sensors 2009, 9, 7398-7411.

AMA Style

Anne M-L, Keirsse J, Nazabal V, Hyodo K, Inoue S, Boussard-Pledel C, Lhermite H, Charrier J, Yanakata K, Loreal O, Le Person J, Colas F, Compère C, Bureau B. Chalcogenide Glass Optical Waveguides for Infrared Biosensing. Sensors. 2009; 9(9):7398-7411.

Chicago/Turabian Style

Anne, Marie-Laure; Keirsse, Julie; Nazabal, Virginie; Hyodo, Koji; Inoue, Satoru; Boussard-Pledel, Catherine; Lhermite, Hervé; Charrier, Joël; Yanakata, Kiyoyuki; Loreal, Olivier; Le Person, Jenny; Colas, Florent; Compère, Chantal; Bureau, Bruno. 2009. "Chalcogenide Glass Optical Waveguides for Infrared Biosensing." Sensors 9, no. 9: 7398-7411.

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