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Chalcogenide Glass Optical Waveguides for Infrared Biosensing
Sciences Chimiques de Rennes, UMR 6226, Equipe Verres & Céramiques, Université Rennes 1, 35042 Rennes, France
Biomedical sensing and Imaging Group, Inst. for Human Science and Biomedical Engineering, National Institution of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan
National Institute for Materials Science, 1-1 Namiki, Tsukuba, 305-0041, Japan
Institut d’Electronique et de Télécommunications de Rennes-Microelectronic, Université Rennes 1, 35042 Rennes, France
FOTON-CCLO, UMR 6082-ENSSAT, Université Rennes 1, 22305 Lannion, France
Dept. of Neurosurgery, Inst. of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
INSERM U522 , IFR 140, University of Rennes 1, Rennes, France
IFREMER, ERT-Service Interfaces et Capteurs, BP 70 29280 Plouzané, France
* Author to whom correspondence should be addressed.
Received: 8 July 2009; in revised form: 4 September 2009 / Accepted: 8 September 2009 / Published: 15 September 2009
Abstract: Due to the remarkable properties of chalcogenide (Chg) glasses, Chg optical waveguides should play a significant role in the development of optical biosensors. This paper describes the fabrication and properties of chalcogenide fibres and planar waveguides. Using optical fibre transparent in the mid-infrared spectral range we have developed a biosensor that can collect information on whole metabolism alterations, rapidly and in situ. Thanks to this sensor it is possible to collect infrared spectra by remote spectroscopy, by simple contact with the sample. In this way, we tried to determine spectral modifications due, on the one hand, to cerebral metabolism alterations caused by a transient focal ischemia in the rat brain and, in the other hand, starvation in the mouse liver. We also applied a microdialysis method, a well known technique for in vivo brain metabolism studies, as reference. In the field of integrated microsensors, reactive ion etching was used to pattern rib waveguides between 2 and 300 μm wide. This technique was used to fabricate Y optical junctions for optical interconnections on chalcogenide amorphous films, which can potentially increase the sensitivity and stability of an optical micro-sensor. The first tests were also carried out to functionalise the Chg planar waveguides with the aim of using them as (bio)sensors.
Keywords: chalcogenide; optical sensor; fibre; planar waveguide
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Anne, M.-L.; Keirsse, J.; Nazabal, V.; Hyodo, K.; Inoue, S.; Boussard-Pledel, C.; Lhermite, H.; Charrier, J.; Yanakata, K.; Loreal, O.; Le Person, J.; Colas, F.; Compère, C.; Bureau, B. Chalcogenide Glass Optical Waveguides for Infrared Biosensing. Sensors 2009, 9, 7398-7411.
Anne M-L, Keirsse J, Nazabal V, Hyodo K, Inoue S, Boussard-Pledel C, Lhermite H, Charrier J, Yanakata K, Loreal O, Le Person J, Colas F, Compère C, Bureau B. Chalcogenide Glass Optical Waveguides for Infrared Biosensing. Sensors. 2009; 9(9):7398-7411.
Anne, Marie-Laure; Keirsse, Julie; Nazabal, Virginie; Hyodo, Koji; Inoue, Satoru; Boussard-Pledel, Catherine; Lhermite, Hervé; Charrier, Joël; Yanakata, Kiyoyuki; Loreal, Olivier; Le Person, Jenny; Colas, Florent; Compère, Chantal; Bureau, Bruno. 2009. "Chalcogenide Glass Optical Waveguides for Infrared Biosensing." Sensors 9, no. 9: 7398-7411.