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Sensors 2007, 7(7), 1216-1223; doi:10.3390/s7071216

Surface Plasmon Spectroscopic Detection of Saxitoxin

1, 2, 3, 4, 4, 2, 2 and 2,*
1 College of Pharmacy, Pusan National University, Pusan 609-735, Korea 2 College of Nanoscience and Nanotechnology, Pusan National University, Pusan 609-735, Korea 3 College of Science and Technology, Jochiwon 339-700, Korea 4 College of Engineering, Kyungpook National University, Taegu 702-701, Korea
* Author to whom correspondence should be addressed.
Received: 18 June 2007 / Accepted: 13 July 2007 / Published: 16 July 2007
(This article belongs to the Special Issue Optical Biosensors)
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For the surface-optoelectronic study of Saxitoxin sensing, we fabricated self-assembled calix[4]arene derivative monolayers as the recognition-functional interfaces ona gold surface. An interaction study between Saxitoxin and calix[4]arene derivativemonolayers were performed using surface plasmon resonance (SPR) spectroscopy. Amongthree calix[4]arene derivatives, calix[4]arene crown ether SAM showed the highestsensitivity to Saxitoxin. The detection limit of this system is three orders of magnitudelower than that of the mouse bioassay which is the current benchmark for Saxitoxindetection.
Keywords: Saxitoxin; surface plasmon resonance; calixarene; self-assembled monolayer (SAM). Saxitoxin; surface plasmon resonance; calixarene; self-assembled monolayer (SAM).
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, H.; Kim, Y.S.; Keum, S.-R.; Kim, S.-H.; Choi, H.-J.; Lee, J.; An, W.G.; Koh, K. Surface Plasmon Spectroscopic Detection of Saxitoxin. Sensors 2007, 7, 1216-1223.

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