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Sensors 2007, 7(7), 1185-1192; doi:10.3390/s7071185
Article

Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface

*  and
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071-Murcia, Spain
* Author to whom correspondence should be addressed.
Received: 12 June 2007 / Accepted: 10 July 2007 / Published: 11 July 2007
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Abstract

A flow-injection pulse amperometric method for determining tacrine, based onion transfer across a plasticized poly(vinyl chloride) (PVC) membrane, was developed. Afour-electrode potentiostat with ohmic drop compensation was used, while a flow-throughcell incorporated the four electrodes and the membrane, which containedtetrabutylammonium tetraphenylborate. The influence of the applied potential and of theflow-injection variables on the determination of tacrine was studied. In the selectedconditions, a linear relationship between peak height and tacrine concentration was foundup to 4x10-5M tacrine. The detection limit was 1x10-7M. Good repeatability was obtained.Some common ions and pharmaceutical excipients did not interfere.
Keywords: Interface between Two Immiscible Electrolyte Solutions; ion amperometry; plasticized polymeric membrane; tacrine determination; flow-injection analysis Interface between Two Immiscible Electrolyte Solutions; ion amperometry; plasticized polymeric membrane; tacrine determination; flow-injection analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ortuño, J.A.; Rueda, C. Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface. Sensors 2007, 7, 1185-1192.

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