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Sensors 2007, 7(7), 1185-1192; doi:10.3390/s7071185
Article

Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface

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Received: 12 June 2007; Accepted: 10 July 2007 / Published: 11 July 2007
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Abstract: A flow-injection pulse amperometric method for determining tacrine, based onion transfer across a plasticized poly(vinyl chloride) (PVC) membrane, was developed. Afour-electrode potentiostat with ohmic drop compensation was used, while a flow-throughcell incorporated the four electrodes and the membrane, which containedtetrabutylammonium tetraphenylborate. The influence of the applied potential and of theflow-injection variables on the determination of tacrine was studied. In the selectedconditions, a linear relationship between peak height and tacrine concentration was foundup to 4x10-5M tacrine. The detection limit was 1x10-7M. Good repeatability was obtained.Some common ions and pharmaceutical excipients did not interfere.
Keywords: Interface between Two Immiscible Electrolyte Solutions; ion amperometry; plasticized polymeric membrane; tacrine determination; flow-injection analysis Interface between Two Immiscible Electrolyte Solutions; ion amperometry; plasticized polymeric membrane; tacrine determination; flow-injection analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ortuño, J.A.; Rueda, C. Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface. Sensors 2007, 7, 1185-1192.

AMA Style

Ortuño JA, Rueda C. Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface. Sensors. 2007; 7(7):1185-1192.

Chicago/Turabian Style

Ortuño, Joaquin A.; Rueda, C. 2007. "Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface." Sensors 7, no. 7: 1185-1192.



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