Sensors 2007, 7(3), 400-409; doi:10.3390/s7030400
Article

A New Tiapride Selective Electrode and Its Clinical Application

Joaquín A. Ortuño email, Vicente Ródenas email, Mª Soledad García email, Mª Isabel Albero email and Concepción Sánchez-Pedreño * email
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain
* Author to whom correspondence should be addressed.
Received: 29 January 2007 / Accepted: 19 March 2007 / Published: 27 March 2007
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Abstract: The construction and electrochemical response characteristics of a poly(vinylchloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide tiapride concentration range (1x10-5-1x10-2 M) with a slope of 57.5±0.2 mV dec-1 of concentration, a detection limit of 4.3x10-6±2.5x10-7 M, a wide working pH range (2-8) and a fast response time (< 5 s). The electrode showed good selectivity towards tiapride with respect to some inorganic and organic compounds. The electrode has been applied to the determination of tiapride in human urine and iontophoresis solution.
Keywords: Ion-selective electrode; tiapride determination; urine; iontophoresis solution.

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MDPI and ACS Style

Ortuño, J.A.; Ródenas, V.; García, M.S.; Albero, M.I.; Sánchez-Pedreño, C. A New Tiapride Selective Electrode and Its Clinical Application. Sensors 2007, 7, 400-409.

AMA Style

Ortuño J.A., Ródenas V., García M.S., Albero M.I., Sánchez-Pedreño C. A New Tiapride Selective Electrode and Its Clinical Application. Sensors. 2007; 7(3):400-409.

Chicago/Turabian Style

Ortuño, Joaquín A.; Ródenas, Vicente; García, Mª Soledad; Albero, Mª Isabel; Sánchez-Pedreño, Concepción. 2007. "A New Tiapride Selective Electrode and Its Clinical Application." Sensors 7, no. 3: 400-409.

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