Next Article in Journal
A Fluorimetric Sensor for Detection of One Living Cell
Previous Article in Journal
Home-made Detection Device for a Mixture of Ethanol and Acetone
Sensors 2007, 7(2), 214-221; doi:10.3390/s7020214

DNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips

1,* , 2, 2, 2, 1, 1 and 1
1 Institute for Microelectronics and Microsystems – Unit of Naples – National Council of Research, Via P. Castellino 111, 80131 Napoli, Italy 2 Department of Biochemistry and Medical Biotechnologies, University of Naples “Federico II”, Via S. Pansini 5, 80131 Napoli, Italy 3 Department of Organic Chemistry and Biochemistry, University of Naples “Federico II”, Via Cinthia, 80128 Napoli, Italy 4 Department of Physical Sciences, University of Naples “Federico II”, Via Cinthia, 80126 Naples, Italy
* Author to whom correspondence should be addressed.
Received: 15 February 2007 / Revised: 26 February 1995 / Accepted: 1 January 2007 / Published: 28 February 2007
View Full-Text   |   Download PDF [130 KB, uploaded 21 June 2014]   |   Browse Figures


A photochemical functionalization process which passivates the porous silicon surface of optical biosensors has been optimized as a function of the thickness and the porosity of the devices. The surface modification has been characterized by contact angle measurements. Fluorescence measurements have been used to investigate the stability of the DNA single strands bound to the nanostructured material. A dose-response curve for an optical label-free biosensor in the 6-80 μM range has been realized.
Keywords: Optical Biosensors; Porous Silicon; Biochip. Optical Biosensors; Porous Silicon; Biochip.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

De Stefano, L.; Arcari, P.; Lamberti, A.; Sanges, C.; Rotiroti, L.; Rea, I.; Rendina, I. DNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips. Sensors 2007, 7, 214-221.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert