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Sensors 2007, 7(2), 214-221; doi:10.3390/s7020214

DNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips

Institute for Microelectronics and Microsystems – Unit of Naples – National Council of Research, Via P. Castellino 111, 80131 Napoli, Italy
Department of Biochemistry and Medical Biotechnologies, University of Naples “Federico II”, Via S. Pansini 5, 80131 Napoli, Italy
Department of Organic Chemistry and Biochemistry, University of Naples “Federico II”, Via Cinthia, 80128 Napoli, Italy
Department of Physical Sciences, University of Naples “Federico II”, Via Cinthia, 80126 Naples, Italy
Author to whom correspondence should be addressed.
Received: 15 February 2007 / Revised: 26 February 1995 / Accepted: 1 January 2007 / Published: 28 February 2007
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A photochemical functionalization process which passivates the porous silicon surface of optical biosensors has been optimized as a function of the thickness and the porosity of the devices. The surface modification has been characterized by contact angle measurements. Fluorescence measurements have been used to investigate the stability of the DNA single strands bound to the nanostructured material. A dose-response curve for an optical label-free biosensor in the 6-80 μM range has been realized. View Full-Text
Keywords: Optical Biosensors; Porous Silicon; Biochip. Optical Biosensors; Porous Silicon; Biochip.

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

De Stefano, L.; Arcari, P.; Lamberti, A.; Sanges, C.; Rotiroti, L.; Rea, I.; Rendina, I. DNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips. Sensors 2007, 7, 214-221.

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