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Sensors 2007, 7(2), 214-221; doi:10.3390/s7020214
Article

DNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips

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Received: 15 February 2007 / Revised: 26 February 1995 / Accepted: 1 January 2007 / Published: 28 February 2007
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Abstract

A photochemical functionalization process which passivates the porous silicon surface of optical biosensors has been optimized as a function of the thickness and the porosity of the devices. The surface modification has been characterized by contact angle measurements. Fluorescence measurements have been used to investigate the stability of the DNA single strands bound to the nanostructured material. A dose-response curve for an optical label-free biosensor in the 6-80 μM range has been realized.
Keywords: Optical Biosensors; Porous Silicon; Biochip. Optical Biosensors; Porous Silicon; Biochip.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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De Stefano, L.; Arcari, P.; Lamberti, A.; Sanges, C.; Rotiroti, L.; Rea, I.; Rendina, I. DNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips. Sensors 2007, 7, 214-221.

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