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Sensors 2007, 7(11), 2723-2740; doi:10.3390/s7112723
Article

Modelling a Peroxidase-based Optical Biosensor

1,* , 1
 and 3
Received: 8 October 2007; Accepted: 9 November 2007 / Published: 14 November 2007
(This article belongs to the Special Issue Optical Biosensors)
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Abstract: The response of a peroxidase-based optical biosensor was modelled digitally.A mathematical model of the optical biosensor is based on a system of non-linear reaction-diffusion equations. The modelling biosensor comprises two compartments, an enzyme layerand an outer diffusion layer. The digital simulation was carried out using finite differencetechnique. The influence of the substrate concentration as well as of the thickness of both theenzyme and diffusion layers on the biosensor response was investigated. Calculations showedcomplex kinetics of the biosensor response, especially at low concentrations of the peroxidaseand of the hydrogen peroxide.
Keywords: optical biosensor; peroxidase; modelling; simulation. optical biosensor; peroxidase; modelling; simulation.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Baronas, R.; Gaidamauskait˙e, E.; Kulys, J. Modelling a Peroxidase-based Optical Biosensor. Sensors 2007, 7, 2723-2740.

AMA Style

Baronas R, Gaidamauskait˙e E, Kulys J. Modelling a Peroxidase-based Optical Biosensor. Sensors. 2007; 7(11):2723-2740.

Chicago/Turabian Style

Baronas, Romas; Gaidamauskait˙e, Evelina; Kulys, Juozas. 2007. "Modelling a Peroxidase-based Optical Biosensor." Sensors 7, no. 11: 2723-2740.



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