Next Article in Journal
Biosensor for Direct Determination of Fenitrothion and EPN Using Recombinant Pseudomonas putida JS444 with Surface Expressed Organophosphorus Hydrolase. 1. Modified Clark Oxygen Electrode
Previous Article in Journal
Silver Solid Amalgam Electrodes as Sensors for Chemical Carcinogens
Article Menu

Export Article

Open AccessArticle
Sensors 2006, 6(4), 453-465; doi:10.3390/s6040453

Mathematical Modeling of Biosensors Based on an Array of Enzyme Microreactors

1
Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, 03225 Vilnius, Lithuania
2
Institute of Mathematics and Informatics, Akademijos 4, 08663 Vilnius, Lithuania
3
Department of Chemistry and Bioengineering, Vilnius Gediminas Technical University, Sauletekio al. 11, 10223 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Received: 30 July 2005 / Accepted: 4 January 2006 / Published: 7 April 2006
View Full-Text   |   Download PDF [187 KB, uploaded 20 June 2014]   |  

Abstract

This paper presents a two-dimensional-in-space mathematical model ofbiosensors based on an array of enzyme microreactors immobilised on a single electrode.The modeling system acts under amperometric conditions. The microreactors were modeledby particles and by strips. The model is based on the diffusion equations containing a non-linear term related to the Michaelis-Menten kinetics of the enzymatic reaction. The modelinvolves three regions: an array of enzyme microreactors where enzyme reaction as well asmass transport by diffusion takes place, a diffusion limiting region where only the diffusiontakes place, and a convective region, where the analyte concentration is maintained constant.Using computer simulation, the influence of the geometry of the microreactors and of thediffusion region on the biosensor response was investigated. The digital simulation wascarried out using the finite difference technique. View Full-Text
Keywords: Reaction-diffusion; modeling; biosensor; microreactor. Reaction-diffusion; modeling; biosensor; microreactor.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Baronas, R.; Ivanauskas, F.; Kulys, J. Mathematical Modeling of Biosensors Based on an Array of Enzyme Microreactors. Sensors 2006, 6, 453-465.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top