Next Article in Journal
Amperometric Sensor Used for Determination of Thiocyanate with a Silver Nanoparticles Modified Electrode
Previous Article in Journal
Samarium (III) Selective Membrane Sensor Based on Tin (IV) Boratophosphate
Sensors 2004, 4(9), 136-146; doi:10.3390/s40900136

Quartz Microbalance Sensor for the Detection of Acrylamide

1, 1, 1,*, 2 and 2,*
1 Institute of Physical und Theoretical Chemistry, University of Bonn, Wegelerstrasse 12, D-53115 Bonn, Germany 2 Kekulé-Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk- Str. 1, D-53121 Bonn, Germany
* Authors to whom correspondence should be addressed.
Received: 30 June 2004 / Accepted: 22 September 2004 / Published: 1 October 2004
View Full-Text   |   Download PDF [271 KB, uploaded 20 June 2014]   |   Browse Figures


Several macrocycles of the Hunter-Vögtle type have been identified as superior host compounds for the detection of small amounts of acrylamide. When coated onto the surface of a quartz microbalance, these compounds serve as highly sensitive and selective sensor-active layers for their use in electronic noses. In this study, differently substituted macrocycles were investigated including an open-chain analogue and a catenane. Their structure and functional groups are correlated with their observed affinities to acrylamide and related acids and amides. The much smaller response of the open-chain compound and the almost absent sensor response of the catenane suggest that binding occurs within the cavity of the macrocycle. Theoretical calculations agree well with the experimental data even though they do not yet take into account the arrangement of the macrocycles in the sensor-active layer. The lower detection limit of acrylamide is 10 parts per billion (ppb), which is impressively low for this type of sensor. Other related compounds such as acrylic acid, propionamide, or propionic acid show no or significantly lower affinities to the macrocycles in these concentration ranges.
Keywords: Electronic noses; acrylamide; food analysis; tetralactam macrocycles; quartz microbalance sensors Electronic noses; acrylamide; food analysis; tetralactam macrocycles; quartz microbalance sensors
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Kleefisch, G.; Kreutz, C.; Bargon, J.; Silva, G.; Schalley, C.A. Quartz Microbalance Sensor for the Detection of Acrylamide. Sensors 2004, 4, 136-146.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert