Next Article in Journal
Previous Article in Journal
Sensors 2004, 4(4), 20-36; doi:10.3390/s40400020
Article

Mathematical Model of the Biosensors Acting in a Trigger Mode

1,* , 2 and 1,3
Received: 12 March 2004; Accepted: 10 May 2004 / Published: 26 May 2004
View Full-Text   |   Download PDF [1065 KB, uploaded 20 June 2014]   |   Browse Figures
Abstract: A mathematical model of biosensors acting in a trigger mode has been developed. One type of the biosensors utilized a trigger enzymatic reaction followed by the cyclic enzymatic and electrochemical conversion of the product (CCE scheme). Other biosensors used the enzymatic trigger reaction followed by the electrochemical and enzymatic product cyclic conversion (CEC scheme). The models were based on diffusion equations containing a non-linear term related to Michaelis-Menten kinetics of the enzymatic reactions. The digital simulation was carried out using the finite difference technique. The influence of the substrate concentration, the maximal enzymatic rate as well as the membrane thickness on the biosensor response was investigated. The numerical experiments demonstrated a significant gain (up to dozens of times) in biosensor sensitivity when the biosensor response was under diffusion control. In the case of significant signal amplification, the response time with triggering was up to several times longer than that of the biosensor without triggering.
Keywords: Biosensor; amperometry; modelling; simulation; amplification Biosensor; amperometry; modelling; simulation; amplification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Baronas, R.; Kulys, J.; Ivanauskas, F. Mathematical Model of the Biosensors Acting in a Trigger Mode. Sensors 2004, 4, 20-36.

AMA Style

Baronas R, Kulys J, Ivanauskas F. Mathematical Model of the Biosensors Acting in a Trigger Mode. Sensors. 2004; 4(4):20-36.

Chicago/Turabian Style

Baronas, Romas; Kulys, Juozas; Ivanauskas, Feliksas. 2004. "Mathematical Model of the Biosensors Acting in a Trigger Mode." Sensors 4, no. 4: 20-36.



Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert