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Sensors 2018, 18(8), 2607; https://doi.org/10.3390/s18082607

Fabrication of a Urea Biosensor for Real-Time Dynamic Fluid Measurement

1
Cooperative Course of Nano-Medical Device Engineering, Hallym University, Chuncheon 24252, Korea
2
Department of Materials Science and Engineering, Hallym University, Chuncheon 24252, Korea
3
Integrative Materials Research Institute, Hallym University, Chuncheon 24252, Korea
4
Nano-Bio Regenerative Medical Institute, College of Medicine, Hallym University, Chuncheon 24252, Korea
*
Author to whom correspondence should be addressed.
Received: 10 July 2018 / Revised: 30 July 2018 / Accepted: 8 August 2018 / Published: 9 August 2018
(This article belongs to the Special Issue Development of Enzymatic Electrochemical Biosensors and Applications)
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Abstract

In this study, a portable urea sensor that monitors the urea concentration in flow conditions was fabricated. We propose an electrochemical sensor that continually measures the urea concentration of samples flowing through it at a constant flow rate in real time. For the electrochemical sensing, a porous silk fibroin membrane with immobilized urease was mounted in a polydimethylsiloxane (PDMS) sensor housing. The fabricated urea sensor elicited linear current–concentration characteristics in the clinically significant concentration range (0.1–20 mM) based on peritoneal dialysis. The sensor maintained the linear current–concentration characteristics during operation in flow conditions. View Full-Text
Keywords: urea biosensor; silk fibroin; amination; flow conditions; real-time monitoring urea biosensor; silk fibroin; amination; flow conditions; real-time monitoring
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Kim, K.; Lee, J.; Moon, B.M.; Seo, Y.B.; Park, C.H.; Park, M.; Sung, G.Y. Fabrication of a Urea Biosensor for Real-Time Dynamic Fluid Measurement. Sensors 2018, 18, 2607.

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