Next Article in Journal
A UWB/Improved PDR Integration Algorithm Applied to Dynamic Indoor Positioning for Pedestrians
Next Article in Special Issue
Resonance Frequency Readout Circuit for a 900 MHz SAW Device
Previous Article in Journal
Methods for Real-Time Prediction of the Mode of Travel Using Smartphone-Based GPS and Accelerometer Data
Previous Article in Special Issue
A Semi-Analytical Solution for the Thickness-Vibration of Centrally Partially-Electroded Circular AT-Cut Quartz Resonators
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Sensors 2017, 17(9), 2057; https://doi.org/10.3390/s17092057

Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications

1
Advanced Wave Sensors S. L., Algepser 24, 46988 Paterna, Spain
2
Centro de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, Camí de Vera S/N, 46022 Valencia, Spain
*
Author to whom correspondence should be addressed.
Received: 21 July 2017 / Revised: 31 August 2017 / Accepted: 5 September 2017 / Published: 8 September 2017
(This article belongs to the Special Issue Acoustic Wave Resonator-Based Sensors)
View Full-Text   |   Download PDF [3629 KB, uploaded 11 September 2017]   |  

Abstract

Acoustic wave resonators have become suitable devices for a broad range of sensing applications due to their sensitivity, low cost, and integration capability, which are all factors that meet the requirements for the resonators to be used as sensing elements for portable point of care (PoC) platforms. In this work, the design, characterization, and validation of a 150 MHz high fundamental frequency quartz crystal microbalance (HFF-QCM) sensor for bio-sensing applications are introduced. Finite element method (FEM) simulations of the proposed design are in good agreement with the electrical characterization of the manufactured resonators. The sensor is also validated for bio-sensing applications. For this purpose, a specific sensor cell was designed and manufactured that addresses the critical requirements associated with this type of sensor and application. Due to the small sensing area and the sensor’s fragility, these requirements include a low-volume flow chamber in the nanoliter range, and a system approach that provides the appropriate pressure control for assuring liquid confinement while maintaining the integrity of the sensor with a good base line stability and easy sensor replacement. The sensor characteristics make it suitable for consideration as the elemental part of a sensor matrix in a multichannel platform for point of care applications. View Full-Text
Keywords: HFF-QCM (high fundamental frequency quartz crystal microbalance); finite element method (FEM); flow cell; biosensor; PoC (point of care); MQCM (monolithic quartz crystal microbalance) HFF-QCM (high fundamental frequency quartz crystal microbalance); finite element method (FEM); flow cell; biosensor; PoC (point of care); MQCM (monolithic quartz crystal microbalance)
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Fernández, R.; García, P.; García, M.; García, J.V.; Jiménez, Y.; Arnau, A. Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications. Sensors 2017, 17, 2057.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top