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Sensors 2017, 17(6), 1256; doi:10.3390/s17061256

Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs

School of Instrument Science and Engineering, Southeast University, Nanjing 210096, China
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Author to whom correspondence should be addressed.
Academic Editor: Vittorio M. N. Passaro
Received: 28 February 2017 / Revised: 17 May 2017 / Accepted: 18 May 2017 / Published: 1 June 2017

Abstract

The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of isolated organs. Four necessary elements (the machine perfusion, the physiological parameter monitoring, the thermostatic control and the oxygenation apparatus) involved in this HMP device are introduced. Especially during the thermostatic control process, a modified Bayes estimation, which introduces the concept of improvement factor, is realized to recognize and reduce the possible measurement errors resulting from sensor faults and noise interference. Also, a fuzzy-PID controller contributes to improve the accuracy and reduces the computational load using the DSP. Our experiments indicate that the reliability of the instrument meets the design requirements, thus being appealing for potential clinical preservation applications. View Full-Text
Keywords: HMP device; physiology parameters monitoring; modified Bayes estimation; fuzzy-PID controller HMP device; physiology parameters monitoring; modified Bayes estimation; fuzzy-PID controller
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shen, F.; Yan, R. Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs. Sensors 2017, 17, 1256.

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