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Sensors 2017, 17(4), 849; doi:10.3390/s17040849

A New Strategy for Silver Deposition on Au Nanoparticles with the Use of Peroxidase-Mimicking DNAzyme Monitored via a Localized Surface Plasmon Resonance Technique

1
Laboratory of Bioanalytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznan, Poland
2
Department of Nano Biophotonics, Leibniz Institute of Photonic Technology (IPHT), 07745 Jena, Germany
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: W. Rudolf Seitz
Received: 8 March 2017 / Revised: 6 April 2017 / Accepted: 10 April 2017 / Published: 13 April 2017
(This article belongs to the Section State-of-the-Art Sensors Technologies)
View Full-Text   |   Download PDF [2248 KB, uploaded 13 April 2017]   |  

Abstract

Peroxidase-mimicking DNAzyme was applied as a catalyst of silver deposition on gold nanoparticles. This DNAzyme is formed when hemin binds to the G-quadruplex-forming DNA sequence. Such a system is able to catalyze a redox reaction with a one- or two-electron transfer. The process of silver deposition was monitored via a localized surface plasmon resonance technique (LSPR), which allows one to record scattering spectrum of a single nanoparticle. Our study showed that DNAzyme is able to catalyze silver deposition. The AFM experiments proved that DNAzyme induced the deposition of silver shells of approximately 20 nm thickness on Au nanoparticles (AuNPs). Such an effect is not observed when hemin is absent in the system. However, we noticed non-specific binding of hemin to the capture oligonucleotides on a gold NP probe that also induced some silver deposition, even though the capture probe was unable to form G-quadruplex. Analysis of SEM images indicated that the surface morphology of the silver layer deposited by DNAzyme is different from that obtained for hemin alone. The proposed strategy of silver layer synthesis on gold nanoparticles catalyzed by DNAzyme is an innovative approach and can be applied in bioanalysis (LSPR, electrochemistry) as well as in material sciences. View Full-Text
Keywords: DNAzyme; silver deposition; LSPR; localized surface plasmon resonance; Au nanoparticles; AuNPs DNAzyme; silver deposition; LSPR; localized surface plasmon resonance; Au nanoparticles; AuNPs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kosman, J.; Jatschka, J.; Csaki, A.; Fritzsche, W.; Juskowiak, B.; Stranik, O. A New Strategy for Silver Deposition on Au Nanoparticles with the Use of Peroxidase-Mimicking DNAzyme Monitored via a Localized Surface Plasmon Resonance Technique. Sensors 2017, 17, 849.

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