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Sensors 2017, 17(3), 588; doi:10.3390/s17030588

DNA Sequencing Sensors: An Overview

1
Department of Biology and Geology, University of Almeria, 04120 Almeria, Spain
2
Department of Chemistry and Physics, University of Almeria, 04120 Almeria, Spain
3
Department of Informatics, University of Almeria, 04120 Almeria, Spain
4
Department of Engineering, University of Almeria, 04120 Almeria, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: María Jesús Lobo-Castañón
Received: 28 January 2017 / Revised: 9 March 2017 / Accepted: 11 March 2017 / Published: 14 March 2017
(This article belongs to the Special Issue Genosensing)
View Full-Text   |   Download PDF [9589 KB, uploaded 14 March 2017]   |  

Abstract

The first sequencing of a complete genome was published forty years ago by the double Nobel Prize in Chemistry winner Frederick Sanger. That corresponded to the small sized genome of a bacteriophage, but since then there have been many complex organisms whose DNA have been sequenced. This was possible thanks to continuous advances in the fields of biochemistry and molecular genetics, but also in other areas such as nanotechnology and computing. Nowadays, sequencing sensors based on genetic material have little to do with those used by Sanger. The emergence of mass sequencing sensors, or new generation sequencing (NGS) meant a quantitative leap both in the volume of genetic material that was able to be sequenced in each trial, as well as in the time per run and its cost. One can envisage that incoming technologies, already known as fourth generation sequencing, will continue to cheapen the trials by increasing DNA reading lengths in each run. All of this would be impossible without sensors and detection systems becoming smaller and more precise. This article provides a comprehensive overview on sensors for DNA sequencing developed within the last 40 years. View Full-Text
Keywords: DNA sequencing; next generation sequencing (NGS); pyrosequencing; fluorescence; semiconductor; nanopore DNA sequencing; next generation sequencing (NGS); pyrosequencing; fluorescence; semiconductor; nanopore
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Garrido-Cardenas, J.A.; Garcia-Maroto, F.; Alvarez-Bermejo, J.A.; Manzano-Agugliaro, F. DNA Sequencing Sensors: An Overview. Sensors 2017, 17, 588.

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