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Sensors 2017, 17(2), 405; doi:10.3390/s17020405

A Biocompatible Colorimetric Triphenylamine- Dicyanovinyl Conjugated Fluorescent Probe for Selective and Sensitive Detection of Cyanide Ion in Aqueous Media and Living Cells

1
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Jong Seung Kim and Min Hee Lee
Received: 12 December 2016 / Revised: 16 January 2017 / Accepted: 4 February 2017 / Published: 19 February 2017
(This article belongs to the Special Issue Colorimetric and Fluorescent Sensor)
View Full-Text   |   Download PDF [3238 KB, uploaded 19 February 2017]   |  

Abstract

A colorimetric and turn-on fluorescent probe 1 bearing triphenylamine-thiophene and dicyanovinyl groups has been synthesized and used to detect cyanide anion via a nucleophilic addition reaction. Probe 1 exhibited prominent selectivity and sensitivity towards CN in aqueous media, even in the presence of other anions such as S2−, HS, SO32−, S2O32−, S2O82−, I, Br, Cl, F, NO2, N3, SO42−, SCN, HCO3, CO32− and AcO. Moreover, a low detection limit (LOD, 51 nM) was observed. In addition, good cell membrane permeability and low cytotoxicity to HeLa cells were also observed, suggesting its promising potential in bio-imaging. View Full-Text
Keywords: biocompatible; cell imaging; colorimetric assay; dicyanovinyl; cyanide anion biocompatible; cell imaging; colorimetric assay; dicyanovinyl; cyanide anion
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MDPI and ACS Style

Zheng, Z.-H.; Li, Z.-K.; Song, L.-J.; Wang, Q.-W.; Huang, Q.-F.; Yang, L. A Biocompatible Colorimetric Triphenylamine- Dicyanovinyl Conjugated Fluorescent Probe for Selective and Sensitive Detection of Cyanide Ion in Aqueous Media and Living Cells. Sensors 2017, 17, 405.

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