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Sensors 2017, 17(11), 2548; https://doi.org/10.3390/s17112548

Synergy Effect of Combining Fluorescence and Mid Infrared Fiber Spectroscopy for Kidney Tumor Diagnostics

1
art photonics GmbH, Rudower Chaussee 46, Berlin 12489, Germany
2
Laboratory of Multivariate Analysis and Global Modeling, Samara State Technical University, Molodogvardeyskaya 244, 443100 Samara, Russia
3
Medical Physics & Optical Diagnostics, CC6 Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
4
Research-Educational Institute of Optics and Biophotonics, Saratov National Research State University, Saratov 410012, Russia
5
Technical University of Berlin, Institute of Optics and Atomic Physics, Berlin 10623, Germany
6
Deptartment of Urology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
*
Author to whom correspondence should be addressed.
Received: 18 September 2017 / Revised: 21 October 2017 / Accepted: 2 November 2017 / Published: 5 November 2017
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Germany)
View Full-Text   |   Download PDF [1627 KB, uploaded 5 November 2017]   |  

Abstract

Matching pairs of tumor and non-tumor kidney tissue samples of four patients were investigated ex vivo using a combination of two methods, attenuated total reflection mid infrared spectroscopy and fluorescence spectroscopy, through respectively prepared and adjusted fiber probes. In order to increase the data information content, the measurements on tissue samples in both methods were performed in the same 31 preselected positions. Multivariate data analysis revealed a synergic effect of combining the two methods for the diagnostics of kidney tumor compared to individual techniques. View Full-Text
Keywords: mid infrared spectroscopy; fluorescence spectroscopy; synergy effect; fiber probe; joint data analysis; cancer diagnostics mid infrared spectroscopy; fluorescence spectroscopy; synergy effect; fiber probe; joint data analysis; cancer diagnostics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bogomolov, A.; Belikova, V.; Zabarylo, U.J.; Bibikova, O.; Usenov, I.; Sakharova, T.; Krause, H.; Minet, O.; Feliksberger, E.; Artyushenko, V. Synergy Effect of Combining Fluorescence and Mid Infrared Fiber Spectroscopy for Kidney Tumor Diagnostics. Sensors 2017, 17, 2548.

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