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Sensors 2016, 16(12), 2061; doi:10.3390/s16122061

Integrating Deoxyribozymes into Colorimetric Sensing Platforms

1
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
2
Department of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4K1, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Jong Seung Kim and Min Hee Lee
Received: 1 November 2016 / Revised: 30 November 2016 / Accepted: 30 November 2016 / Published: 3 December 2016
(This article belongs to the Special Issue Colorimetric and Fluorescent Sensor)
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Abstract

Biosensors are analytical devices that have found a variety of applications in medical diagnostics, food quality control, environmental monitoring and biodefense. In recent years, functional nucleic acids, such as aptamers and nucleic acid enzymes, have shown great potential in biosensor development due to their excellent ability in target recognition and catalysis. Deoxyribozymes (or DNAzymes) are single-stranded DNA molecules with catalytic activity and can be isolated to recognize a wide range of analytes through the process of in vitro selection. By using various signal transduction mechanisms, DNAzymes can be engineered into fluorescent, colorimetric, electrochemical and chemiluminescent biosensors. Among them, colorimetric sensors represent an attractive option as the signal can be easily detected by the naked eye. This reduces reliance on complex and expensive equipment. In this review, we will discuss the recent progress in the development of colorimetric biosensors that make use of DNAzymes and the prospect of employing these sensors in a range of chemical and biological applications. View Full-Text
Keywords: DNAzymes; biosensors; colorimetric sensors DNAzymes; biosensors; colorimetric sensors
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Chang, D.; Zakaria, S.; Deng, M.; Allen, N.; Tram, K.; Li, Y. Integrating Deoxyribozymes into Colorimetric Sensing Platforms. Sensors 2016, 16, 2061.

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