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Sensors 2016, 16(1), 6; doi:10.3390/s16010006

Application of Carbon-Microsphere-Modified Electrodes for Electrochemistry of Hemoglobin and Electrocatalytic Sensing of Trichloroacetic Acid

Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China
Author to whom correspondence should be addressed.
Academic Editors: Yu Lei, Ashutosh Tiwari and Hongyun Liu
Received: 29 October 2015 / Revised: 28 November 2015 / Accepted: 17 December 2015 / Published: 23 December 2015
(This article belongs to the Special Issue Microbial and Enzymatic Biosensors)
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By using the hydrothermal method, carbon microspheres (CMS) were fabricated and used for electrode modification. The characteristics of CMS were investigated using various techniques. The biocompatible sensing platform was built by immobilizing hemoglobin (Hb) on the micrometer-sized CMS-modified electrode with a layer of chitosan membrane. On the cyclic voltammogram, a couple of quasi-reversible cathodic and anodic peaks appeared, showing that direct electrochemistry of Hb with the working electrode was achieved. The catalytic reduction peak currents of the bioelectrode to trichloroacetic acid was established in the linear range of 2.0~70.0 mmol·L−1 accompanied by a detection limit of 0.30 mmol·L−1 (3σ). The modified electrode displayed favorable sensitivity, good reproducibility and stability, which suggests that CMS is promising for fabricating third-generation bioelectrochemical sensors. View Full-Text
Keywords: hemoglobin; carbon microsphere; direct electrochemistry; trichloroacetic acid hemoglobin; carbon microsphere; direct electrochemistry; trichloroacetic acid

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, W.-C.; Yan, L.-J.; Shi, F.; Niu, X.-L.; Huang, G.-L.; Zheng, C.-J.; Sun, W. Application of Carbon-Microsphere-Modified Electrodes for Electrochemistry of Hemoglobin and Electrocatalytic Sensing of Trichloroacetic Acid. Sensors 2016, 16, 6.

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