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Sensors 2015, 15(3), 4913-4924; doi:10.3390/s150304913

Engineering a Ca++-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel

1
Department of Biosciences, University of Milan, Via Celoria 26, Milano 20133, Italy
2
Institute of Biophysics-Milan section, National Research Council, Via Celoria 26, Milano 20133, Italy
3
Department of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 3, Darmstadt 64287, Germany
Present Addresses: CNRS UMR-5203, Institut de Génomique Fonctionnelle, Départment de Physiologie, LabEx ICST, 141 rue de la Cardonille, 34094 Montpellier cedex 5, France; INSERM U1191, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France
*
Author to whom correspondence should be addressed.
Academic Editor: Stefano Mariani
Received: 17 November 2014 / Revised: 19 December 2014 / Accepted: 2 February 2015 / Published: 27 February 2015
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Italy 2014)
View Full-Text   |   Download PDF [1797 KB, uploaded 27 February 2015]   |  

Abstract

Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes in intracellular cell calcium concentration and allows an easy read out by converting the calcium signal into an electrical current in the range of microampere that can be easily measured by conventional cell electrophysiology apparatus. View Full-Text
Keywords: biosensor; Kcv; calcium; calmodulin; synthetic ion channel biosensor; Kcv; calcium; calmodulin; synthetic ion channel
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

DiFrancesco, M.L.; Gazzarrini, S.; Arrigoni, C.; Romani, G.; Thiel, G.; Moroni, A. Engineering a Ca++-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel. Sensors 2015, 15, 4913-4924.

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