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Sensors 2014, 14(7), 11844-11854; doi:10.3390/s140711844
Article

Miniaturizable Ion-Selective Arrays Based on Highly Stable Polymer Membranes for Biomedical Applications

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Received: 7 May 2014; in revised form: 21 June 2014 / Accepted: 2 July 2014 / Published: 4 July 2014
(This article belongs to the Special Issue Ion Selective Electrodes for Bioavailable Ions)
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Abstract: Poly(vinylchloride) (PVC) is the most common polymer matrix used in the fabrication of ion-selective electrodes (ISEs). However, the surfaces of PVC-based sensors have been reported to show membrane instability. In an attempt to overcome this limitation, here we developed two alternative methods for the preparation of highly stable and robust ion-selective sensors. These platforms are based on the selective electropolymerization of poly(3,4-ethylenedioxythiophene) (PEDOT), where the sulfur atoms contained in the polymer covalently interact with the gold electrode, also permitting controlled selective attachment on a miniaturized electrode in an array format. This platform sensor was improved with the crosslinking of the membrane compounds with poly(ethyleneglycol) diglycidyl ether (PEG), thus also increasing the biocompatibility of the sensor. The resulting ISE membranes showed faster signal stabilization of the sensor response compared with that of the PVC matrix and also better reproducibility and stability, thus making these platforms highly suitable candidates for the manufacture of robust implantable sensors.
Keywords: ion-selective electrode (ISE) sensor; pH detection; ischemia; electrochemistry; implantable device; biomedicine; endoscope ion-selective electrode (ISE) sensor; pH detection; ischemia; electrochemistry; implantable device; biomedicine; endoscope
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mir, M.; Lugo, R.; Tahirbegi, I.B.; Samitier, J. Miniaturizable Ion-Selective Arrays Based on Highly Stable Polymer Membranes for Biomedical Applications. Sensors 2014, 14, 11844-11854.

AMA Style

Mir M, Lugo R, Tahirbegi IB, Samitier J. Miniaturizable Ion-Selective Arrays Based on Highly Stable Polymer Membranes for Biomedical Applications. Sensors. 2014; 14(7):11844-11854.

Chicago/Turabian Style

Mir, Mònica; Lugo, Roberto; Tahirbegi, Islam B.; Samitier, Josep. 2014. "Miniaturizable Ion-Selective Arrays Based on Highly Stable Polymer Membranes for Biomedical Applications." Sensors 14, no. 7: 11844-11854.


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