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Sensors 2014, 14(11), 21140-21150; doi:10.3390/s141121140

A Coumarin-Based Fluorescent Probe as a Central Nervous System Disease Biomarker

1
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
2
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
3
Department of Chemistry, Hankuk University of Foreign Studies, Yongin 449-791, Korea
*
Author to whom correspondence should be addressed.
Received: 17 September 2014 / Revised: 18 October 2014 / Accepted: 29 October 2014 / Published: 10 November 2014
(This article belongs to the Special Issue Advances in Optical Biosensors)
View Full-Text   |   Download PDF [341 KB, uploaded 10 November 2014]   |  

Abstract

Homocysteine and methylmalonic acid are important biomarkers for diseases associated with an impaired central nervous system (CNS). A new chemoassay utilizing coumarin-based fluorescent probe 1 to detect the levels of homocysteine is successfully implemented using Parkinson’s disease (PD) patients’ blood serum. In addition, a rapid identification of homocysteine and methylmalonic acid levels in blood serum of PD patients was also performed using the liquid chromatography-mass spectrometry (LC-MS). The results obtained from both analyses were in agreement. The new chemoassay utilizing coumarin-based fluorescent probe 1 offers a cost- and time-effective method to identify the biomarkers in CNS patients. View Full-Text
Keywords: fluorescent probe; fluorescence spectroscopy; mass spectrometry; homocysteine; methylmalonic acid; neurochemistry; chemoassay fluorescent probe; fluorescence spectroscopy; mass spectrometry; homocysteine; methylmalonic acid; neurochemistry; chemoassay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yap, A.-C.; Mahamad, U.A.; Lim, S.-Y.; Kim, H.-J.; Choo, Y.-M. A Coumarin-Based Fluorescent Probe as a Central Nervous System Disease Biomarker. Sensors 2014, 14, 21140-21150.

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