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Sensors 2014, 14(10), 18211-18222;

Single-Molecule Study of Proteins by Biological Nanopore Sensors

College of Pharmacy, Jiamusi University, Jiamusi 154007, China
The Affiliated First Hospital of Jiamusi University, Jiamusi 154007, China
Authors to whom correspondence should be addressed.
Received: 24 May 2014 / Revised: 31 August 2014 / Accepted: 19 September 2014 / Published: 29 September 2014
(This article belongs to the Special Issue Nanopore Sensors: Fabrications, Properties and Applications)
View Full-Text   |   Download PDF [2640 KB, uploaded 29 September 2014]


Nanopore technology has been developed for detecting properties of proteins through monitoring of ionic current modulations as protein passes via a nanosize pore. As a real-time, sensitive, selective and stable technology, biological nanopores are of widespread concern. Here, we introduce the background of nanopore researches in the area of α-hemolysin (α-HL) nanopores in protein conformation detections and protein–ligand interactions. Moreover, several original biological nanopores are also introduced with various features and functions. View Full-Text
Keywords: α-hemolysin; protein conformation; protein-ligand interactions; new nanopores α-hemolysin; protein conformation; protein-ligand interactions; new nanopores
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wu, D.; Bi, S.; Zhang, L.; Yang, J. Single-Molecule Study of Proteins by Biological Nanopore Sensors. Sensors 2014, 14, 18211-18222.

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