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Open AccessCommunication
Sensors 2012, 12(9), 11922-11932; doi:10.3390/s120911922

In Vivo Histamine Optical Nanosensors

Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
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Received: 7 June 2012 / Revised: 20 August 2012 / Accepted: 24 August 2012 / Published: 29 August 2012
(This article belongs to the Special Issue Ultra-Small Sensor Systems and Components)
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Abstract

In this communication we discuss the development of ionophore based nanosensors for the detection and monitoring of histamine levels in vivo. This approach is based on the use of an amine-reactive, broad spectrum ionophore which is capable of recognizing and binding to histamine. We pair this ionophore with our already established nanosensor platform, and demonstrate in vitro and in vivo monitoring of histamine levels. This approach enables capturing rapid kinetics of histamine after injection, which are more difficult to measure with standard approaches such as blood sampling, especially on small research models. The coupling together of in vivo nanosensors with ionophores such as nonactin provide a way to generate nanosensors for novel targets without the difficult process of designing and synthesizing novel ionophores.
Keywords: nanosensor; optode; histamine; in vivo nanosensor; optode; histamine; in vivo
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Cash, K.J.; Clark, H.A. In Vivo Histamine Optical Nanosensors. Sensors 2012, 12, 11922-11932.

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