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In Vivo Histamine Optical Nanosensors
Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
* Author to whom correspondence should be addressed.
Received: 7 June 2012; in revised form: 20 August 2012 / Accepted: 24 August 2012 / Published: 29 August 2012
Abstract: In this communication we discuss the development of ionophore based nanosensors for the detection and monitoring of histamine levels in vivo. This approach is based on the use of an amine-reactive, broad spectrum ionophore which is capable of recognizing and binding to histamine. We pair this ionophore with our already established nanosensor platform, and demonstrate in vitro and in vivo monitoring of histamine levels. This approach enables capturing rapid kinetics of histamine after injection, which are more difficult to measure with standard approaches such as blood sampling, especially on small research models. The coupling together of in vivo nanosensors with ionophores such as nonactin provide a way to generate nanosensors for novel targets without the difficult process of designing and synthesizing novel ionophores.
Keywords: nanosensor; optode; histamine; in vivo
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MDPI and ACS Style
Cash, K.J.; Clark, H.A. In Vivo Histamine Optical Nanosensors. Sensors 2012, 12, 11922-11932.
Cash KJ, Clark HA. In Vivo Histamine Optical Nanosensors. Sensors. 2012; 12(9):11922-11932.
Cash, Kevin J.; Clark, Heather A. 2012. "In Vivo Histamine Optical Nanosensors." Sensors 12, no. 9: 11922-11932.