A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma
AbstractA fluorescent probe for glutathione (GSH) detection was developed. Our study indicates a possible mechanism which couples a conjugate addition and micelle-catalyzed large membered ring formation/elimination sequence. This method enables excellent selectivity towards GSH over other biological thiols such as cysteine (Cys) and homocysteine (Hcy). The proposed method is precise with a relative standard deviation (R.S.D) lower than 6% (n = 3) and has been successfully applied to determine GSH in human plasma with recoveries between 99.2% and 102.3%.
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Guo, Y.; Yang, X.; Hakuna, L.; Barve, A.; Escobedo, J.O.; Lowry, M.; Strongin, R.M. A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma. Sensors 2012, 12, 5940-5950.
Guo Y, Yang X, Hakuna L, Barve A, Escobedo JO, Lowry M, Strongin RM. A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma. Sensors. 2012; 12(5):5940-5950.Chicago/Turabian Style
Guo, Yixing; Yang, Xiaofeng; Hakuna, Lovemore; Barve, Aabha; Escobedo, Jorge O.; Lowry, Mark; Strongin, Robert M. 2012. "A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma." Sensors 12, no. 5: 5940-5950.