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Sensors 2012, 12(4), 4661-4696; doi:10.3390/s120404661
Review

Quorum Quenching Revisited—From Signal Decays to Signalling Confusion

1, 2, 2, 1 and 1,*
Received: 28 February 2012; in revised form: 23 March 2012 / Accepted: 26 March 2012 / Published: 10 April 2012
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Abstract: In a polymicrobial community, while some bacteria are communicating with neighboring cells (quorum sensing), others are interrupting the communication (quorum quenching), thus creating a constant arms race between intercellular communication. In the past decade, numerous quorum quenching enzymes have been found and initially thought to inactivate the signalling molecules. Though this is widely accepted, the actual roles of these quorum quenching enzymes are now being uncovered. Recent evidence extends the role of quorum quenching to detoxification or metabolism of signalling molecules as food and energy source; this includes “signalling confusion”, a term coined in this paper to refer to the phenomenon of non-destructive modification of signalling molecules. While quorum quenching has been explored as a novel anti-infective therapy targeting, quorum sensing evidence begins to show the development of resistance against quorum quenching.
Keywords: acylase; anti-infective; anti-biofouling; aquaculture; lactonase; N-acylhomoserine lactone; paraoxonase; oxidoreductase; quorum sensing; quorum quenching resistance; signalling confusion acylase; anti-infective; anti-biofouling; aquaculture; lactonase; N-acylhomoserine lactone; paraoxonase; oxidoreductase; quorum sensing; quorum quenching resistance; signalling confusion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hong, K.-W.; Koh, C.-L.; Sam, C.-K.; Yin, W.-F.; Chan, K.-G. Quorum Quenching Revisited—From Signal Decays to Signalling Confusion. Sensors 2012, 12, 4661-4696.

AMA Style

Hong K-W, Koh C-L, Sam C-K, Yin W-F, Chan K-G. Quorum Quenching Revisited—From Signal Decays to Signalling Confusion. Sensors. 2012; 12(4):4661-4696.

Chicago/Turabian Style

Hong, Kar-Wai; Koh, Chong-Lek; Sam, Choon-Kook; Yin, Wai-Fong; Chan, Kok-Gan. 2012. "Quorum Quenching Revisited—From Signal Decays to Signalling Confusion." Sensors 12, no. 4: 4661-4696.



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