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Sensors 2011, 11(6), 5968-5980; doi:10.3390/s110605968

Cytochrome C Biosensor—A Model for Gas Sensing

* ,
Sony Deutschland GmbH, Materials Science Laboratory, Hedelfinger Strasse 61, 70327 Stuttgart, Germany
* Author to whom correspondence should be addressed.
Received: 14 April 2011 / Accepted: 23 May 2011 / Published: 1 June 2011
(This article belongs to the Special Issue Bioinspired Sensor Systems)
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This work is about gas biosensing with a cytochrome c biosensor. Emphasis is put on the analysis of the sensing process and a mathematical model to make predictions about the biosensor response. Reliable predictions about biosensor responses can provide valuable information and facilitate biosensor development, particularly at an early development stage. The sensing process comprises several individual steps, such as phase partition equilibrium, intermediate reactions, mass-transport, and reaction kinetics, which take place in and between the gas and liquid phases. A quantitative description of each step was worked out and finally combined into a mathematical model. The applicability of the model was demonstrated for a particular example of methanethiol gas detection by a cytochrome c biosensor. The model allowed us to predict the optical readout response of the biosensor from tabulated data and data obtained in simple liquid phase experiments. The prediction was experimentally verified with a planar three-electrode electro-optical cytochrome c biosensor in contact with methanethiol gas in a gas tight spectroelectrochemical measurement cell.
Keywords: cytochrome c; biosensor; thiol; prediction; model; sensing process cytochrome c; biosensor; thiol; prediction; model; sensing process
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hulko, M.; Hospach, I.; Krasteva, N.; Nelles, G. Cytochrome C Biosensor—A Model for Gas Sensing. Sensors 2011, 11, 5968-5980.

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