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Sensors 2010, 10(7), 6623-6661; doi:10.3390/s100706623
Review

Microfluidic Systems for Biosensing

1,* , 2
, 3
, 2
, 4
 and 2,5,*
1 School of Engineering, University of Warwick, Coventry CV4 7AL, UK 2 Department of Engineering and System Science, National Tsing-Hua University, Hsinchu, Taiwan 3 Department of Biomedical Engineering, Ming Chuang University, Taoyuan County 333, Taiwan 4 Department of Mechanical and Mechatronic Engineering, National Taiwan Ocean University, Keelung 202-24, Taiwan 5 Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan
* Authors to whom correspondence should be addressed.
Received: 1 June 2010 / Revised: 20 June 2010 / Accepted: 30 June 2010 / Published: 9 July 2010
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in the UK)
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Abstract

In the past two decades, Micro Fluidic Systems (MFS) have emerged as a powerful tool for biosensing, particularly in enriching and purifying molecules and cells in biological samples. Compared with conventional sensing techniques, distinctive advantages of using MFS for biomedicine include ultra-high sensitivity, higher throughput, in-situ monitoring and lower cost. This review aims to summarize the recent advancements in two major types of micro fluidic systems, continuous and discrete MFS, as well as their biomedical applications. The state-of-the-art of active and passive mechanisms of fluid manipulation for mixing, separation, purification and concentration will also be elaborated. Future trends of using MFS in detection at molecular or cellular level, especially in stem cell therapy, tissue engineering and regenerative medicine, are also prospected.
Keywords: lab-on-a-chip; Micro total analysis systems (µTAS); droplet-based; microfluidic; MEMS; tissue engineering; stem cell; drug delivery lab-on-a-chip; Micro total analysis systems (µTAS); droplet-based; microfluidic; MEMS; tissue engineering; stem cell; drug delivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liu, K.-K.; Wu, R.-G.; Chuang, Y.-J.; Khoo, H.S.; Huang, S.-H.; Tseng, F.-G. Microfluidic Systems for Biosensing. Sensors 2010, 10, 6623-6661.

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