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Responsive Hydrogels for Label-Free Signal Transduction within Biosensors
Biophysics and Medical Technology, Department of Physics, The Norwegian University of Science and Technology, NTNU NO-7491 Trondheim, Norway
NTNU NanoLab, The Norwegian University of Science and Technology, NTNU NO-7491 Trondheim, Norway
* Author to whom correspondence should be addressed.
Received: 1 March 2010; in revised form: 12 April 2010 / Accepted: 23 April 2010 / Published: 30 April 2010
Abstract: Hydrogels have found wide application in biosensors due to their versatile nature. This family of materials is applied in biosensing either to increase the loading capacity compared to two-dimensional surfaces, or to support biospecific hydrogel swelling occurring subsequent to specific recognition of an analyte. This review focuses on various principles underpinning the design of biospecific hydrogels acting through various molecular mechanisms in transducing the recognition event of label-free analytes. Towards this end, we describe several promising hydrogel systems that when combined with the appropriate readout platform and quantitative approach could lead to future real-life applications.
Keywords: biospecific hydrogels; biosensors
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MDPI and ACS Style
Gawel, K.; Barriet, D.; Sletmoen, M.; Stokke, B.T. Responsive Hydrogels for Label-Free Signal Transduction within Biosensors. Sensors 2010, 10, 4381-4409.
Gawel K, Barriet D, Sletmoen M, Stokke BT. Responsive Hydrogels for Label-Free Signal Transduction within Biosensors. Sensors. 2010; 10(5):4381-4409.
Gawel, Kamila; Barriet, David; Sletmoen, Marit; Stokke, Bjørn Torger. 2010. "Responsive Hydrogels for Label-Free Signal Transduction within Biosensors." Sensors 10, no. 5: 4381-4409.