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Sensors 2010, 10(5), 4381-4409; doi:10.3390/s100504381

Responsive Hydrogels for Label-Free Signal Transduction within Biosensors

1 Biophysics and Medical Technology, Department of Physics, The Norwegian University of Science and Technology, NTNU NO-7491 Trondheim, Norway 2 NTNU NanoLab, The Norwegian University of Science and Technology, NTNU NO-7491 Trondheim, Norway
* Author to whom correspondence should be addressed.
Received: 1 March 2010 / Revised: 12 April 2010 / Accepted: 23 April 2010 / Published: 30 April 2010
(This article belongs to the Special Issue Advances in Transducers)
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Hydrogels have found wide application in biosensors due to their versatile nature. This family of materials is applied in biosensing either to increase the loading capacity compared to two-dimensional surfaces, or to support biospecific hydrogel swelling occurring subsequent to specific recognition of an analyte. This review focuses on various principles underpinning the design of biospecific hydrogels acting through various molecular mechanisms in transducing the recognition event of label-free analytes. Towards this end, we describe several promising hydrogel systems that when combined with the appropriate readout platform and quantitative approach could lead to future real-life applications.
Keywords: biospecific hydrogels; biosensors biospecific hydrogels; biosensors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gawel, K.; Barriet, D.; Sletmoen, M.; Stokke, B.T. Responsive Hydrogels for Label-Free Signal Transduction within Biosensors. Sensors 2010, 10, 4381-4409.

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