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Sensors 2010, 10(11), 9948-9962; doi:10.3390/s101109948

Application of Sensing Techniques to Cellular Force Measurement

1
Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi St, Suzhou, Jiangsu 215006, China
2
Orthopedic Institute, Soochow University, 708 Renmin Rd, Suzhou, Jiangsu 215007, China
3
MechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, and Mechanical Engineering and Materials Science, University of Pittsburgh, 210 Lothrop St, BST, E1640, Pittsburgh, PA 15213, USA
*
Author to whom correspondence should be addressed.
Received: 20 September 2010 / Revised: 22 October 2010 / Accepted: 25 October 2010 / Published: 5 November 2010
(This article belongs to the Special Issue Sensors in Biomechanics and Biomedicine)
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Abstract

Cell traction forces (CTFs) are the forces produced by cells and exerted on extracellular matrix or an underlying substrate. CTFs function to maintain cell shape, enable cell migration, and generate and detect mechanical signals. As such, they play a vital role in many fundamental biological processes, including angiogenesis, inflammation, and wound healing. Therefore, a close examination of CTFs can enable better understanding of the cellular and molecular mechanisms of such processes. To this end, various force-sensing techniques for CTF measurement have been developed over the years. This article will provide a concise review of these sensing techniques and comment on the needs for improved force-sensing technologies for cell mechanics and biology research. View Full-Text
Keywords: cell traction force; measurement; cell force monitor; micropost force sensor array; cell traction force microscopy cell traction force; measurement; cell force monitor; micropost force sensor array; cell traction force microscopy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, B.; Wang, J.-C. Application of Sensing Techniques to Cellular Force Measurement. Sensors 2010, 10, 9948-9962.

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