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Application of Sensing Techniques to Cellular Force Measurement
Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi St, Suzhou, Jiangsu 215006, China
Orthopedic Institute, Soochow University, 708 Renmin Rd, Suzhou, Jiangsu 215007, China
MechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, and Mechanical Engineering and Materials Science, University of Pittsburgh, 210 Lothrop St, BST, E1640, Pittsburgh, PA 15213, USA
* Author to whom correspondence should be addressed.
Received: 20 September 2010; in revised form: 22 October 2010 / Accepted: 25 October 2010 / Published: 5 November 2010
Abstract: Cell traction forces (CTFs) are the forces produced by cells and exerted on extracellular matrix or an underlying substrate. CTFs function to maintain cell shape, enable cell migration, and generate and detect mechanical signals. As such, they play a vital role in many fundamental biological processes, including angiogenesis, inflammation, and wound healing. Therefore, a close examination of CTFs can enable better understanding of the cellular and molecular mechanisms of such processes. To this end, various force-sensing techniques for CTF measurement have been developed over the years. This article will provide a concise review of these sensing techniques and comment on the needs for improved force-sensing technologies for cell mechanics and biology research.
Keywords: cell traction force; measurement; cell force monitor; micropost force sensor array; cell traction force microscopy
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MDPI and ACS Style
Li, B.; Wang, J.-C. Application of Sensing Techniques to Cellular Force Measurement. Sensors 2010, 10, 9948-9962.
Li B, Wang J-C. Application of Sensing Techniques to Cellular Force Measurement. Sensors. 2010; 10(11):9948-9962.
Li, Bin; Wang, James H.-C. 2010. "Application of Sensing Techniques to Cellular Force Measurement." Sensors 10, no. 11: 9948-9962.