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Sensors 2001, 1(3), 75-90; doi:10.3390/s10300075

Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements

School of Chemistry, The University of New South Wales, Sydney 2052, Australia
Authors to whom correspondence should be addressed.
Received: 27 July 2001 / Accepted: 27 July 2001 / Published: 8 August 2001
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Amino acids and peptides are known to bind metal ions, in some cases very strongly. There are only a few examples of exploiting this binding in sensors. The review covers the current literature on the interaction of peptides and metals and the electrochemistry of bound metal ions. Peptides may be covalently attached to surfaces. Of particular interest is the attachment to gold via sulfur linkages. Sulfur-containing peptides (eg cysteine) may be adsorbed directly, while any amino group can be covalently attached to a carboxylic acid-terminated thiol. Once at a surface, the possibility for using the attached peptide as a sensor for metal ions becomes realised. Results from the authors’ laboratory and elsewhere have shown the potential for selective monitoring of metal ions at ppt levels. Examples of the use of poly-aspartic acid and the copper binding peptide Gly-Gly-His for detecting copper ions are given. View Full-Text
Keywords: Metal ion sensors; Amino acids; Peptides; Electrochemistry Metal ion sensors; Amino acids; Peptides; Electrochemistry

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MDPI and ACS Style

Gooding, J.J.; Hibbert, D.B.; Yang, W. Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements. Sensors 2001, 1, 75-90.

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