Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements
AbstractAmino acids and peptides are known to bind metal ions, in some cases very strongly. There are only a few examples of exploiting this binding in sensors. The review covers the current literature on the interaction of peptides and metals and the electrochemistry of bound metal ions. Peptides may be covalently attached to surfaces. Of particular interest is the attachment to gold via sulfur linkages. Sulfur-containing peptides (eg cysteine) may be adsorbed directly, while any amino group can be covalently attached to a carboxylic acid-terminated thiol. Once at a surface, the possibility for using the attached peptide as a sensor for metal ions becomes realised. Results from the authors’ laboratory and elsewhere have shown the potential for selective monitoring of metal ions at ppt levels. Examples of the use of poly-aspartic acid and the copper binding peptide Gly-Gly-His for detecting copper ions are given. View Full-Text
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Gooding, J.J.; Hibbert, D.B.; Yang, W. Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements. Sensors 2001, 1, 75-90.
Gooding JJ, Hibbert DB, Yang W. Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements. Sensors. 2001; 1(3):75-90.Chicago/Turabian Style
Gooding, J. J.; Hibbert, D. B.; Yang, Wenrong. 2001. "Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements." Sensors 1, no. 3: 75-90.