Electrochemical Characterisation and Application of Multi Microelectrode Array Devices to Biological Electrochemistry

doi:10.3390/s10100018

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Sensors 2001, 1(1), 18-28; doi:10.3390/s10100018

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Electrochemical Characterisation and Application of Multi Microelectrode Array Devices to Biological Electrochemistry

Michael Kudera ¹, H. A.O. Hill ¹^,* , Peter J. Dobson ², Peter A. Leigh ² and William S. McIntire ³

¹ Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, UK
² Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK
³ Molecular Biology Division, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, U.S.A. and Department of Biochemistry and Biophysics and Department of Anesthesia, University of California, San Francisco, CA 94143, USA

^* Author to whom correspondence should be addressed.

Received: 29 May 2001 / Accepted: 14 June 2001 / Published: 20 June 2001

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Abstract: A new design for microelectrode array (MEA) devices fabricated by semiconductor-processing techniques is presented. The microelectrode surfaces consist of gold and are surrounded by an insulating silicon nitride layer. Each chip of these so-called Multi MEAs contains regular arrays with circular-shaped electrodes of eight different sizes: 1, 3, 5, 10, 50, 100, 500 and 1000μm. The Multi MEAs were electrochemically characterised by use of ferrocenecarboxylic acid. Well-defined cyclic voltammograms of the two small redox proteins, horse heart cytochrome c and amicyanin from Thiobacillus versutus, were obtained at variously surface-modified Multi MEAs. Furthermore, a very simple method to manufacture Multi MEAs with carbon surfaces is introduced.

Keywords: Microelectrode array; bioelectrochemical sensor; direct protein electrochemistry; cytochrome c; amicyanin

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MDPI and ACS Style

Kudera, M.; Hill, H.A.O.; Dobson, P.J.; Leigh, P.A.; McIntire, W.S. Electrochemical Characterisation and Application of Multi Microelectrode Array Devices to Biological Electrochemistry. Sensors 2001, 1, 18-28.

AMA Style

Kudera M., Hill H.A.O., Dobson P.J., Leigh P.A., McIntire W.S. Electrochemical Characterisation and Application of Multi Microelectrode Array Devices to Biological Electrochemistry. Sensors. 2001; 1(1):18-28.

Chicago/Turabian Style

Kudera, Michael; Hill, H. A.O.; Dobson, Peter J.; Leigh, Peter A.; McIntire, William S. 2001. "Electrochemical Characterisation and Application of Multi Microelectrode Array Devices to Biological Electrochemistry." Sensors 1, no. 1: 18-28.

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