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Molbank 2018, 2018(3), M1009; https://doi.org/10.3390/M1009

2-{[(4-Hydroxy-3,5-dimethoxyphenyl)methylidene]hydrazinylidene}-4-oxo-1,3-thiazolidin-5-yl Acetic Acid

1
Department of Studies in Chemistry, Mangalore University, Mangalagangothri, Karnataka-574199, India
2
Department of Studies in Biosciences, Mangalore University, Mangalagangothri, Karnataka-574199, India
3
Department of Industrial Chemistry, Mangalore University, Mangalagangothri, Karnataka-574199, India
*
Author to whom correspondence should be addressed.
Received: 5 July 2018 / Revised: 23 July 2018 / Accepted: 27 July 2018 / Published: 29 July 2018
(This article belongs to the Section Organic Synthesis)
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Abstract

Thia-Michael addition of 2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]hydrazine-1-carbothioamide (1) with maleic anhydride results in the formation of the title compound 2-{[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]hydrazinylidene}-4-oxo-1,3-thiazolidin-5-yl acetic acid 2. The precursor 1 is synthesized by the reaction of 4-hydroxy-3,5-dimethoxybenzaldehyde and thiosemicarbazide in the presence of glacial acetic acid as the catalyst. The structure of the title compound is determined by elemental analysis, FT-IR, 1H-NMR, 13C-NMR and mass spectral data. In order to determine the molecular interactions with the bacterial enzyme, the title compound is further docked into the active site of the MurB protein of Staphylococcus aureus (PDB ID: 1HSK). The in vitro antibacterial and antifungal activity of the title compound is carried out in order to appraise its antimicrobial efficacy by determination of zone of inhibition and minimal inhibitory concentration. The compound is also evaluated for its antioxidant property by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging assay. View Full-Text
Keywords: Thia-Michael addition; maleic anhydride; in vitro antimicrobial evaluation; molecular docking; DPPH radical scavenging assay Thia-Michael addition; maleic anhydride; in vitro antimicrobial evaluation; molecular docking; DPPH radical scavenging assay
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Karanth, S.; Narayana, B.; Kodandoor, S.C.; Sarojini, B.K. 2-{[(4-Hydroxy-3,5-dimethoxyphenyl)methylidene]hydrazinylidene}-4-oxo-1,3-thiazolidin-5-yl Acetic Acid. Molbank 2018, 2018, M1009.

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