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Molbank 2018, 2018(1), M979; doi:10.3390/M979


Institute of Biochemistry and Biophysics Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland
Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland
Institute of Genetics and Biotechnology, Faculty of Biology, University of Warszaw, Pawinskiego 5a, 02-106 Warsaw, Poland
Author to whom correspondence should be addressed.
Received: 22 December 2017 / Revised: 26 January 2018 / Accepted: 28 January 2018 / Published: 30 January 2018
(This article belongs to the Special Issue Heterocycles)
View Full-Text   |   Download PDF [2042 KB, uploaded 30 January 2018]   |  


N-(4-Bromobenzyl)-2-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)benzeneamine was obtained by condensation of N-(4-bromobenzyl)-3,1-benzoxazine-2,4-dione (N-(4-bromobenzyl)isatoic anhydride) with 4,5-dimethyl-1,2-phenylenediamine in refluxing acetic acid. This is a rare example of condensation of N-substituted 3,1-benzoxazine-2,4-dione with 1,2-phenylenediamine, which resulted in the formation of a benzimidazole derivative with a moderate yield. Crystallographic studies and initial biological screening were performed for the obtained product. View Full-Text
Keywords: substituted benzimidazoles; 3,1-benzoxazine-2,4-dione; isatoic anhydride; 1,2-phenylenediamine; crystallographic studies; cytotoxicity substituted benzimidazoles; 3,1-benzoxazine-2,4-dione; isatoic anhydride; 1,2-phenylenediamine; crystallographic studies; cytotoxicity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dziełak, M.; Trzybiński, D.; Czerwińska, J.; Majchrzak, B.; Tudek, B.; Woźniak, K.; Mieczkowski, A. N-(4-Bromobenzyl)-2-(5,6-dimethyl-1H-benzo[d]imid-azol-2-yl)benzeneamine. Molbank 2018, 2018, M979.

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