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Molbank 2017, 2017(2), M942; doi:10.3390/M942

Ethyl 7-Methyl-1-(4-nitrophenyl)-5-phenyl-3-(thiophen-2-yl)-1,5-dihydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate

1
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
2
Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt
3
Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Received: 13 March 2017 / Revised: 2 May 2017 / Accepted: 8 May 2017 / Published: 19 May 2017
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [867 KB, uploaded 19 May 2017]   |  

Abstract

A novel compound, ethyl 7-methyl-1-(4-nitrophenyl)-5-phenyl-3-(thiophen-2-yl)-1,5-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate (7) was synthesized by reaction of N-(4-nitrophenyl)thiophene-2-carbohydrazonoyl chloride (1) with ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (2). The mechanism of the studied reaction is discussed and the assigned structure was confirmed by elemental analysis and spectral data. Moreover, the in vitro antitumor activities against human lung (A-549) and human hepatocellular carcinoma (HepG-2) cell lines were determined by the MTT method, and the results indicated a high potency compared with the employed standard antitumor drug (Cisplatin). View Full-Text
Keywords: hydrazonoyl chlorides; pyrimidinethiones; triaolopyrimidines; antitumor activity hydrazonoyl chlorides; pyrimidinethiones; triaolopyrimidines; antitumor activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gomha, S.M.; Muhammad, Z.A.; Edrees, M.M. Ethyl 7-Methyl-1-(4-nitrophenyl)-5-phenyl-3-(thiophen-2-yl)-1,5-dihydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate. Molbank 2017, 2017, M942.

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